TIRTL-seq: Deep, quantitative, and affordable paired TCR repertoire sequencing biorxiv.org/cgi/content/sh… #biorxiv_immuno

TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 biorxiv.org/content/10.110… (1/11)

Preprint alert 🚨 Up to 90% CAR knock-in rates in primary human T cells - without drug enhancers? 🧐 Single-stranded HDR templates with truncated Cas12a binding sequences improve knock-in efficiencies in primary human T cells biorxiv.org/content/10.110… 🧵👇

To order free Covid tests (US) covidtests.gov

Result of a rewarding experience to summarize our knowledge on meningeal biology with established experts in the field below. I hope this provides inspiration for further research studies aiming to find the truth. rdcu.be/dVigd

Just out: mRNA COVID-19 vax do not establish in long-lived plasma cells; could account for faster waning vs. infection. Other mechanisms still protect durably vs. severe illness, but improving durability is important. Adjuvants (like in Novavax) may help. nature.com/articles/s4159…

Cytotoxic #Tcells have distinct pro-inflammatory signatures in people with #MultipleSclerosis, according to a new twin study in Science #Immunology. scim.ag/8oa

B Cells Influence Encephalitogenic T Cell Frequency to Myelin Oligodendrocyte Glycoprotein (MOG)38–49 during Full-length MOG Protein–Induced Demyelinating Disease Evavold Lab journals.aai.org/immunohorizons…

Abstract submissions are NOW OPEN for the T Cells in the Brain symposium TCB2025 tcellsbrain.org ! We are offering 10 travel awards to support national and international trainees ✈️ #neuroimmunology #tcells #Alzheimers #Parkinson’s # ALS #Epilepsy #MS

Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain: Trends in Neurosciences cell.com/trends/neurosc…

A Stanford study links Epstein-Barr virus (EBV) to autoimmune diseases like lupus and multiple sclerosis, suggesting it triggers autoimmunity through molecular mimicry and B cell reprogramming. nature.com/articles/s4158…

We are recruiting a young researcher to join our dynamic lab at UCSF - this is a great opportunity if you would like to get some research experience before graduate or medical school! aprecruit.ucsf.edu/JPF05305. Please RT!