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The broccoli derivative sulforaphane extends lifespan by slowing the transcriptional aging clock biorxiv.org/content/10.110…

Would you like to start your lab College of Medicine and Health (UoB) ? The Birmingham Springboard Fellowships provide 2 years of funding to allow you to develop your independent research and apply for external fellowships. Come join us Uni of Birmingham ! Deadline: Sep 3, 2025. birmingham.ac.uk/research/activ…

New updates in the #DrugAge database: nature.com/articles/s4151… "Our analysis revealed correlations between weight loss and #lifespan extension in male mice, and sex-related differences in lifespan and weight change responses." By Aleksey V. Belikov, Angelo Talay, João Pedro de Magalhães

NEW paper 🚨 We updated the mouse data in DrugAge to reveal sex-related differences in lifespan and weight effects. We found that, mostly in males, drug-induced life extension in mice correlates with weight loss. Amazing effort by aleksey ! nature.com/articles/s4151…

The pace and shape of ant ageing onlinelibrary.wiley.com/doi/10.1111/br…

It’s our birthday this Sunday! 🎉 125 years ago, Queen Victoria granted our Royal Charter - bringing Joseph Chamberlain’s radical vision to life as England’s first civic university: birmingham.ac.uk/university/his… Now swipe to travel back in time...

The first principle is that you must not fool yourself — and you are the easiest person to fool.

‘Medical Antifreeze’: How to Freeze and Thaw Brain Tissue medscape.com/viewarticle/me…

Had a great visit to Københavns Uni Thank you for the chance to give a seminar and grateful for the thoughtful questions and discussions.

Impressive work showing that "many functionally young-like clones persist in old age". This again illustrates how ageing is a very heterogeneous process where, due to (epi)mutations, you end up with mosaics of cells that are a mix of functional and nonfunctional cells.

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice nature.com/articles/s4432…

Thank you Csaba Kerepesi for the invitation to present our computational work on ageing Hungarian Research Network | HUN-REN Institute for Computer Science and Control in stunning Budapest. In silico methods are crucial to tackle the complexity of biology and gather insights into ageing and longevity.

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan-Extending Compounds onlinelibrary.wiley.com/doi/10.1111/ac…

Fascinating work by David Gems UCL on osteoarthritis (OA) from a programmatic perspective 🤯 His framework is that OA is caused by programmatic changes that prime chondrocytes for futile program activation as a form of antagonistic pleiotropy. sciencedirect.com/science/articl…

GIMM Fest | Aging and Longevity: Registrations open now! September 4-6 2025, Portugal, Lisbon. The brand new Gulbenkian Institute, launching – the very first GIMM Festival – "Aging and Longevity" to explore the future of aging through science. gimm.pt/gimm-festival/

Signatures of Nonlinear Aging: Molecular Stages of Life onlinelibrary.wiley.com/doi/10.1002/bi…

Combining two drugs (trametinib and rapamycin) resulted in one of the greatest life-extensions observed in mice - 27% (males) and 29% (females). Both are anticancer drugs and treatment reduced tumor load, though other benefits were observed (eg reduced inflammation).

Peto’s paradox’s relevance is off the scale aging-us.com/article/206258…

"The Top Five Regrets of the Dying" by Bronnie Ware outlines what people most regret on their deathbed, namely: 1. Not following one’s dreams 2. Working too hard 3. Not expressing one’s feelings 4. Not keeping in touch with friends 5. Not letting oneself be happier

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions nature.com/articles/s4358…