This graph is so great as PRS just crushes BP or hypertension which makes sense as the loci barely overlap, but it’s hard to convince cardiologists of this!

#gus

Kamala really said

Very generous write up from Scott Damrauer that nicely weaves in pointers to important future directions.

There is nothing warmer than a still 65 degree night in San Francisco.

As someone whose technical job* can be automated by LLMs to varying degrees, it’s a pleasure seeing people work on techniques for automating procedural jobs too. * my real job is being a liability sponge

This is apparently how professionals speak to medical trainees on twitter dot com?

New on the The Lancet-JACC Journals collaboration! We detail our joint efforts to accelerate progress in global cardiovascular health. Read about our work towards better heart health for all. American College of Cardiology #ESCCongress authors.elsevier.com/a/1jgxA2d9GH%7…

Exciting Fri at #ESCCongress for JACC Journals and our authors publishing groundbreaking research: 5 LATE BREAKING SCIENCE papers Many semaglutide studies (STEP-HFpEF, FLOW, SELECT) and much more… #CardioTwitter #ESC2024 American College of Cardiology Mikhail Kosiborod Subodh Verma scottdavidsolomon

JACC is on 🔥 it is THE place for top cardiology science Amazing work by Harlan Krumholz JACC Journals American College of Cardiology

In the large randomized trial of GLP-1 semaglutide for obesity, there was a significant reduction of all-cause mortality, deaths from Covid and serious adverse events from Covid jacc.org/doi/10.1016/j.… JACC Journals #ESCCongress2024

#SimPub #CircESC2024 Lifelong LDL-C levels, driven by rare genetic variants, significantly influence aortic stenosis (AS) risk. Findings suggest that early & sustained lipid-lowering therapy could be key in preventing AS. ahajournals.org/doi/10.1161/CI…

Does elevated LDL cause aortic stenosis? 🥓🫀🩺 Excited to share our study linking rare LDL-associated genetic variants to aortic stenosis 🧬 Published in @Circulation and presented at #ESCCongress2024 today Broad Institute UCSF Health Link: ahajournals.org/doi/10.1161/CI…

Is LDL-C a causal risk factor for aortic stenosis? We're excited to see our study now in Circulation examining this question by leveraging rare protein-disrupting variants in UK Biobank and AllofUsResearch. With Sean Jurgens, Shino Kany, Patrick Ellinor & James 🥥🏈 Pirruccello.

Joel Rämö Circulation UK Biobank AllofUsResearch Sean Jurgens Shino Kany Patrick Ellinor James 🥥🏈 Pirruccello Nice work. I recently said at a meeting that I was skeptical of the association between LDL and AS because of confounding. But I think I'm ready to change my mind!

I am honored and thrilled to take on the role of Division Director for Genetic Medicine VUMC Department of Medicine! As a junior faculty member, I benefited tremendously from mentorship and support from Nancy J Cox. I look forward to paying it forward Vanderbilt Genetics Institute!

So informative analysis! We often compare PRSs to sets of clinical predictors but rarely to single ones For intracerebral hemorrhage, we also found that PRS offers the largest improvement in c-index among clinical factors (larger than hypertension)! ahajournals.org/doi/10.1161/ST…

Feels like Waymo has had a recent regression where the car will change its drop-off location mid-trip without notifying you. I promise I enthusiastically never want to get dropped off on Market Street if I selected a side-street dropoff…

Cardiovascular Care of Tactical Athletes: Have We Landed Yet? jacc.org/doi/10.1016/j.…