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1/12 🚨 Diagnostics save lives, but building a business around them is another story. Why do so many promising tests fail to achieve financial or clinical success? The problem isn’t bad science—it’s brutal math. Here’s what diagnostic innovators need to know: 🧵👇

7/ What can diagnostic entrepreneurs learn from this? 1️⃣ Prioritize specificity to improve predictive value. 2️⃣ Target high-value markets. 3️⃣ Solve unmet needs where existing tests fail. 4️⃣ Win beyond the test with convenience, speed, or impact on care.

Johnny Yu, Nima Alidoust, Kevan Shokat, and I are excited to announce a historic achievement by our team at Vevo Therapeutics: Tahoe-100M, a 100M single-cell transcriptomic atlas, measuring how thousands of drugs impact cells from 50 diverse cancer lines. prnewswire.com/news-releases/…

Indians are probably inventors on dozens of patents filed every single day by America's dominant tech sector. America isn't whiteness. It is the land of opportunity for the world's best and brightest. We maintain our dominance through competition rather than ethnic protection.

These debates are always overly reductive. To climb a mountain, you need to point in the right direction (strategy) and move quickly (execution). Progress is a vector. But dedicated strategy roles are a red flag early on. Strategy and execution need tight coupling at the outset.

Twenty-five years ago I took a class at Harvard from a member of the Institute of Medicine (now the NAM) where he lamented the ethical dilemma of spending more money on vaccine safety studies for a skeptical public when they have already been so well studied. Yet here we are.

If you have any vaccine skeptical friends or family, forward them this plain-language explanation of why vaccines are genuine miracles of modern science.

Personalized cancer vaccines keep putting up big wins — there is renewed hope in the war on cancer. (maybe don't hamstring NIH funding right now?)

I always knew it was time to go to sleep when I heard the trash truck at 4am. CS was brutal.

This American wants to thank the people of Ukraine for laying their lives on the line to keep Europe, and the greater Western world, free.

One step closer to

If anybody at Google Gemini App is out there, your abuse detection system probably has a 99.99% false positive rate — and with no way around it, a large proportion of people affected have no choice but to go to OpenAI for 20x the price

My 8yo's teacher told her to make multiplication flash cards to practice with. Under five minutes on Rork and we have an ipad app that tracks her streaks and looks and feels like a human made it

People are sleeping on Gemini's biggest natural advantage: cost. Who cares if o1 or 2.5-pro is marginally better when 2.5-pro is 1/10th the price. It's hard to beat Google's investment in verticalized infrastructure.

We'll know we have ASI when an AI can figure out React effect chains

San Francisco seems to have rapidly improved since my last visit after a decade of steady decline. Could the boom loop be real??

A fun pastime with Cursor is to add an elaborate comment and hope the tab-suggestion whips it up for you without extra thought. And then some days you hold your breath and get: # TODO: implement this