Thank you Trends in Biochemical Sciences for inviting Marie Cronin and me to contribute a Spotlight on work from Ruhma Syeda and team: "Subconductance states add complexity to Piezo1 gating model". #Piezos #IonChannels #Biophysics #Neuroscience authors.elsevier.com/a/1jAZH3S6GfQZ…

Incredible fun to join my wife ⁦@robingrandl⁩ for her 25-year ⁦#techreunions ⁦⁦⁦Massachusetts Institute of Technology (MIT)⁩, including our bridge loop.

Stayed at ⁦Massachusetts Institute of Technology (MIT)⁩ dorms. Zero comfort and 100% flair! We recommend!

A pervasive view is that TRP channels represent primary sensors of mechanical forces. Along with @PooleLab1 and Boris Martinac we reviewed the evidence supporting this in Trends in Biochemical Sciences cell.com/trends/biochem…

I highly recommend scientific writing services from "The Sustainable Professor" Elizabeth Haswell. Liz provided me with clear, constructive, and timely feedback that elevated my science and writing. Thank you @ehaswell thesustainableprofessor.com

Incredible days Gordon Research Conferences "Ion Channels". Ardem Patapoutian labbies, alumni, and lab members share their science #Piezos #Mechanotransduction #IonChannels.

Please RT. The Franks Lab at Duke U. is hiring a neuroscience tech! We study perception, learning & decision-making using the mouse olfactory system. Learn more here: thefrankslab.org. #Neuroscience #ResearchJobs #DukeUniversity #ScienceJobs

Work from Amanda Lewis and Marie Cronin now published Neuron. Piezo 1 ion channels can signal to other nearby membrane proteins just by changing their shape: doi.org/10.1016/j.neur…

Many thanks to Duke Today for featuring our work: today.duke.edu/2024/07/bodys-…

Postdoctoral Fellow position available in my lab to study mechanically-activated Piezo #ionchannels rohacslab.org/position-avail…

Our paper on regulation of Piezo2 #ionchannels by phosphatidic acid is published in Nature Communications. Congratulations to first author Matthew Gabrielle, Ph.D. who did an amazing job !!!! nature.com/articles/s4146…

We report the 3D architecture and mechanism of touch detection by the Pacinian corpuscle. Contrary to the textbook knowledge, the outer core is dispensable for frequency detection. A new study by Luke Ziolkowski and Yury Nikolaev biorxiv.org/content/10.110…

Debra Silver, PhD, has been honored with the 2024 Javits Award from NIH for her groundbreaking work on intellectual disability and autism. Her research on radial glia cells continues to illuminate the complexities of neurological disorders. Debby Silver medschool.duke.edu/news/debra-sil…

Preprint just dropped!🎙️We discover molecular mechanisms of the excruciatingly painful sting of the Scarlet Velvet Ant (Dasymutilla occidentalis). Title: "Multiple mechanisms of action of an extremely painful venom." 🧵 1/N biorxiv.org/content/10.110…

Uterine scar after C-section can lead to placenta accreta, which can necessitate hysterectomy. Paper shows scar matrix activates mechanosensitive #Piezo1 #ionchannel, and leads to recruiting invading trophoblasts towards scar, initiating placenta accreta: nature.com/articles/s4146…

What proteins surround PIEZO1 on the cell surface? We used a mass spec proteomic approach to capture a snapshot of the PIEZO1 interactome. One of these candidates, CADM1/SynCAM, slows the inactivation kinetics of PIEZO1 with little effect on PIEZO2. pnas.org/doi/10.1073/pn…

Come see us at #SfN2024 in Chicago! The Duke Neurobiology Graduate Training Program booth will be open from 📅Saturday to Tuesday, ⏰12-2 PM. Meet with students, faculty, and learn about joining our world-class research community Duke Neurobiology!

The Duke Neurobiology⁩ Booth is Open #SfN2024 Come visit us ⁦Duke Neurobiology⁩

Happy to share our new review of TRP channel structural pharmacology that describes 40 sites of TRP channel regulation discovered by now! Ira Talyzina Kirill Nadezhdin sciencedirect.com/science/articl…

From now on please follow me on Bluesky: bsky.app/profile/jorggr…