$ALPN $VRTX a reminder that great targets are the most precious resource in drug development

Kudos to $RVMD for testing their drugs on real mouse tumors with genetically defined mutations

Most companies just use xenografts or cell lines and that is why you often hear that curing mice is easy. It's not

nature.com/articles/s4158…

How is that for a Euro listing: Spanish cosmetics group Puig looks to raise $2.7bn in local IPO

reuters.com/markets/deals/…

Do I really need a VPN to be able to use Claude? FFS

Richard Dawkins’ “The Ancestor’s Tale” is orders of magnitude better than “The Selfish Gene”

Twitter ads used to be bad, now they are epically bad

Synergy between two drugs is overrated. If you have a combo with non-overlapping mechanisms and compatible tox that gives you a purely additive effect, that is already an outstanding result

Is there a bigger question in science than quantum gravity? Quantum mechanics and general relativity don't explain one another. How is it that we still rely on two incompatible 100-year old paradigms to explain the fundamental laws of physics?

A lot of the recent sizable pharma M&A has been focused on building technological capabilities rather than replacing immediate revenue loss: ADC platforms, radiopharmaceuticals…

Can’t accuse pharma of not taking risks this time around

“God is dead. God remains dead. And we have killed him. How shall we comfort ourselves, the murderers of all murderers?”

I love it when Perplexity shamelessly quotes Wikipedia to answer a complex scientific question

The FDA is getting serious about confirmatory trials being 'well underway' before they grant accelerated approval. This has a very significant impact on the financing strategies of development-stage biotech companies

Biotech stocks are the perfect example of reflexivity in financial markets: The better the fundamentals are perceived→ the higher the stock price→ the higher the chances of the fundamentals to work

Higher stock price means longer runway, better hires, larger clinical trials..

Genetically engineered pig kidney transplanted into a human patient, a first by eGenesis

The patient is doing well and has been able to stop dialysis

businesswire.com/news/home/2024…

There's a rumor that someone used Bitcoin to buy a pizza many years ago. No other instances of its use as a currency have been reported

#investment I We're thrilled to announce that we invested in the $157M #financing of #EngrailTherapeutics
👉bit.ly/43s6Wvc

🎯Transformational #therapies to improve the lives of patients with devastating #neuropsychiatric and #neurodevelopmental disorders

#vc #CNS

They say you only really understand something if you can explain it simply. If that’s the case, then LLMs understand. Deeply

💰 📢 We are thrilled to share the acquisition of our #Nasdaqlisted portfolio company Fusion Pharmaceuticals $FUSN by AstraZeneca for $2.4 billion.

🎯 Accelerating Development Of Next-Generation #Radioconjugates To Treat #Cancer

👉 bit.ly/3TlUxV6

#vc #biotech #oncology

Circular reasoning in fundamental biology:

- 'Evolution is driven by natural selection, where the fittest individuals survive and have more offspring'

BUT how do you define fitness? It's the ability of individuals to survive and have more offspring

Any physicist in my feed that can help with this riddle:

- Newton’s first law: A body remains at rest or in constant motion unless acted upon by a force
- BUT what is a force? A force is any action that changes the motion of a body

How is this not circular reasoning?