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Excited to share a new work from Kipnis Lab by amazing Wenqing Gao (twitter-less) on developing engineered T cell therapy for CNS injury || nature.com/articles/s4158…

WashU Medicine researchers have developed a method using engineered immune cells to reduce spinal cord injury damage in mice, leading to improved recovery, and showing promise for future human therapy. #neuroimmunology medicine.wustl.edu/news/novel-imm…

My bad… our amazing Wenqing Gao is apparently on Twitter and is now telling me she will be more active here! Please follow her Wenqing Gao

Our approach represents the first attempt at using CD4+ T cell therapy for CNS injury, and we’re just getting started (we already have promising preliminary results in mouse models of neurodegenerative diseases).

Lead authors, Wenqing Gao and Min Woo Kim, alongside their team, identified that CD4+ T cell clones in mice 🐭 exhibit antigen specificity towards self-peptides of #myelin and #neuronal proteins. Jonathan Kipnis 💔 🖨️ nature | go.nature.com/3z7btbA

The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed tumour-targeting T cells of the immune system in skull bones near the cancer site go.nature.com/3Mxr1Zf

Nature research paper: Engineered T cell therapy for central nervous system injury go.nature.com/3Xu86oq

Primary CD4+ T cells, engineered to transiently express reconstituted spinal cord injury (SCI)-associated TCRs, demonstrated neuroprotective efficacy in optic nerve injury and SCI models by modulating myeloid cells via IFNγ. nature.com/articles/s4158… #NBThighlight

🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! UVA Research BIG_UVA UVA Neurology

Mind blowing 🤩👏Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/sc…

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