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doi.org/10.1093/nar/gk… DNA plectoneme pinning by base pair mismatches - thanks Keir et al. for a great collaboration!

ATP-dependent and supercoil-sensing DNA compaction by SMC5/6 - thanks to the D'Amours lab for involving us in this exciting project! pubmed.ncbi.nlm.nih.gov/33301731/

"DNA tension-modulated translocation and loop extrusion by SMC complexes revealed by molecular dynamics simulations" disq.us/t/3vkncij with S. Nomidis, @Gruber_Lausanne and John F Marko

Now in eLife - the journal - how the much-loved nuclear protein HP1α controls nuclear shape and mechanics, stiffens mitotic chromosomes, and boosts mitotic reliability, via dimerization+chromatin cross-bridging: elifesciences.org/articles/63972 - a project facilitated by 4DNucleome and @NCIPhySci

Revised preprint - Stefanos Nimodis' MD simulations of the loop-capture model of SMC complexes biorxiv.org/content/10.110… DNA in the tripartite ring and broken symmetry of the complex itself permit processive translocation via large (up to 200 nm) steps

I am recruiting a postdoctoral researcher (grant-funded position available now) interested in DNA-protein interactions and genome organization, using single-molecule techniques including magnetic tweezers and fluorescence approaches. markolab.bmbcb.northwestern.edu/marko/position…

Published! Stefanos Nomidis' MD simulations of SMC complexes translocating and loop-extruding according to the model of Diebold-Durand et al. (Mol. Cell. 2017) academic.oup.com/nar/advance-ar…

Amidst a lot of noise about our fair nation becoming a "geriatric oligarchy" I blundered across this 2014 academic paper cambridge.org/core/journals/… Things have improved since 2014, right?

Ban assault weapons now. sign.moveon.org/petitions/ban-…

Cop on a Rooftop is in full effect at Dunkin located 1900 Dempster. We’re here until noon. Stop by and help support the Special Olympics and our local athletes! #CopOnARooftop

Dr. Ron Biggs has set up a really great #YouTube library of #chromosome manipulation movies plus some lab classics - including detailed video protocols. Let us know if you find them useful! youtube.com/channel/UC980J…

To avoid piles of corporate nonsense in every new tab in Edge I embarked on a quest to have new tabs load a user-defined URL. Apparently possible only by adding a 3rd-party browser extension, e.g., microsoftedge.microsoft.com/addons/detail/… It works but I'm sure the victory is only temporary.

Just returned from the Topoisomeases in Biology and Medicine meeting case.fiu.edu/news-events/to… Thanks so much to organizers Yuk-Ching Tse-Dinh, Dagmar Klostermeier, Valerie Lamour Valerie Lamour and John Nitiss for running a great meeting!

In case anyone is left out there, I'm pleased to report that Dr. Ning Liu's paper on mechanics of meitotic metaphase chromosomes, dependence on #cohesin #aging and #toxins was just published in eLife elifesciences.org/articles/97403 Enjoy!

Subchromosomal mechanics of pericentric and centromeric chromatin along stretched mitotic chromosomes - surprise is little effect of CENP-N and -C degradation on CENP-A organization pubmed.ncbi.nlm.nih.gov/39937678/ From Ron Biggs and StraightLab #centromere #kinetochore #chromosome

Why did the US government decide to start funding science and training young scientists? Worth reading this answer written in 1945 - for the moment still posted on the U.S. National Science Foundation website at nsf-gov-resources.nsf.gov/2023-04/Endles…

Commemorate the life and science of our dear departed colleague Jon Widom - this Thurs May 15 1230 pm in Pancoe Auditorium Northwestern MolBioSci Northwestern - our distinguished Widom Lecturer is Prof. Lucy Bai Penn State - Chromatin Accessibility and the 3D Genome