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We are hiring new faculty members: talent.stjude.org/careers/jobs/1… Our state-of-the-art Technology Core Centers, staffed by expert scientists, empower integrative structural biology. stjude.org/research/depar… please RT!!

Should I or shouldn’t I?

I hadn't seen this app before, but a quick play with it makes me think it is a very nice tool for making very nice images for manuscripts and talks - particularly cartoon-esque ones that simplify complicated assemblies...

Protein AI tweeps... if I 'design' a new binding protein using RosettaFold Diffusion, there are often some sidechain clashes. I remember someone telling me that there is a server you can iron those out with via a little MD - but I can't remember what it was (getting old)! Help!

Oh my goodness...

Amazing opportunity for emerging academic leaders working on the toughest problems our world is facing. Are you looking for a highly interdisciplinary environment with some of the world’s best research talent and infrastructure? Apply now!!! Please retweet 🙏

Current BET inhibitors bind all family members. We used mRNA display to find the first BET bromodomain ligands with (up to ~60-fold) paralogue level specificity. Oddly, structures don’t explain the specificity – dynamics at play? tinyurl.com/5bs5fzjx Payne Research Group Louise Walport

Melibe viridis is basically a carnivorous sea slug with a gelatinous vacuum cleaner for a head: in fact the nudibranch has an oral veil that can expand into a "fish net" to eat its prey [read more: bit.ly/2wkkbBv] [📹 ow.ly/vhJp30mHwpq]

Pretty interesting - the uplift across the board is massive for hard targets, now that everyone is incorporating AF2 into their pipelines... (and worth noting there is a new version of AF2 that is better for complexes - AF2-v2.30...

I'll second that - very cool!

Go Taylor!

Yep - I can say I haven't seen that before...

Robert Smith of The Cure turns 65 today. In one sentence, he provided the most British response ever to hyped-up American popular culture.

Amazing story from the lab down the corridor - Rezwan Siddiquee working with Sandro Ataide and Ruth Hall in Sydney Uni Life&Env at Sydney Science - now they will be thrown into the gladiators' pit I suspect with the other protagonists that prowl this landscape! :-) Great piece of work!

Have been off X for months but had to log in to see response to AF3. I am much less smart than the authors - but am I (and Erin) the only ones to think that the helical afros that it makes out of IDRs is totally weird? Am I missing something?

Wanted: postdoc biochemist/structural biologist to work with Richard Payne, Sydney/US startup INSAMO (and me). Goal: use cyclic peptide mRNA display to design cell-permeable peptide-based protein degraders: usyd.wd105.myworkdayjobs.com/USYD_EXTERNAL_… Email for more info: [email protected]