AlphaDIA enables End-to-End Transfer Learning for Feature-Free Proteomics biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N ... biorxiv.org/cgi/content/sh… #biorxiv_biochem

A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins dlvr.it/T7lZDf

(BioRxiv All) A novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins dlvr.it/T7lgnm (RSS) #BioRxiv #MassSpecRSS

1/7 Matthias Mann Lab and Georg Wallmann Georg Wallmann are proud to announce alphaDIA, our open source, next generation DIA search engine. Check out the preprint bioRxiv biorxiv.org/content/10.110…

AlphaDIA enables End-to-End Transfer Learning for Feature-Free Proteomics biorxiv.org/content/10.110… --- #proteomics #prot-preprint

Missed the Thermo User meeting at on Sunday on the new targeted MS? Our preprint on the Stellar MS shows how to use it in combination with the Orbitrap Astral and Evosep One to design 15N labeled protein based assays. Check out Maria Wahle’s poster ThP733 biorxiv.org/content/10.110…

Incredibly proud of Matthias Mann for winning this year's Dr. H.P. Heineken Prize for Biochemistry and Biophysics together with Ruedi Aebersold! Their pioneering work has transformed protein research and is reshaping the future of biomedicine! #proteomics heinekenprizes.org/2024/06/11/rue…

Happy to announce that our new lab in Berlin Deutsches Herzzentrum der Charité is recruiting! We are offering PhD and postdoc positions. Join our exciting journey to discover and to translate novel mechanism in thromboinflammation - within an fantastic team -apply: karriere.charite.de/en/job-vacanci…

Fantastic four day symposium in beautiful and sunny Copenhagen: "MS Proteomics + AI in Personalized Medicine". Kudos to the Benzon Foundation, our fantastic speakers, and all participants. The ideas and collaborations sparked here will move clinical proteomics forward!

If you are at #hupo2024 in Dresden, do catch up with our lab-mates to know more about some of our exciting research in Matthias Mann Lab 👇

The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends #JProteomeRes pubs.acs.org/doi/10.1021/ac…

Are you interested to learn more about the circulating blood proteome? If so, here's a review that covers new and emerging technologies, advances, challenges, proteoforms, vesicles, protein networks, antibodies, and microsamples. Human Proteome pubs.acs.org/doi/10.1021/ac…

The 68th Benzon Symposium report is now online in Molecular & Cellular Proteomics ! Fantastic conference that brought together top global experts in Copenhagen to translate proteomics to the clinics - from technological advances to regulatory frameworks! Matthias Mann Lab bit.ly/3AsuN3X

🔓 #OpenAccess + Most Read in the past 30 days: "The Circulating Proteome─Technological Developments, Current Challenges, and Future Trends" go.acs.org/bEe

Our PCA-N method with neutralization step enables direct enzymatic digestion, doubles proteome depth from 5µL neat plasma, and scales to 10K+ sample preps/day. Democratizing plasma proteomics with validation across 50K measurements. On bioRxiv! biorxiv.org/content/10.110…

How can an adaptive framework overcome missing values in mass spectrometry proteomics data to enable direct clinical diagnoses from individual patient samples?medRxiv Max Planck Institute of Biochemistry (MPIB) "An adaptive, continuous-learning framework for clinical decision-making from

Check out ADAPT-MS: our flexible, scalable diagnostic framework that transforms discovery plasma proteomics directly into clinical decisions. Dynamic retraining enables single-sample diagnostics for any task - no imputation or fixed panels needed. doi.org/10.1101/2025.0…

To bead or not to bead? We evaluate five plasma proteomics workflows, finding bead-based methods enhance detection but show high susceptibility to cellular contamination bias. Strategies to optimize biomarker discovery in plasma proteomics. doi.org/10.1101/2025.0…

New approach tackles studying rare pediatric diseases! We developed an ontology-guided clustering framework using SNOMED CT to analyze proteomes from 1,140 children across 394 conditions - enabling meaningful insights even with tiny patient numbers! embopress.org/doi/full/10.10…