Had a great time speaking at #CGSBanff today- Thanks GlycoNet for the opportunity!

ICYMI: Jack Babulic & Chantelle Capicciotti Queen's University describe a general method for the display of sugar derivatives on cell-surface #glycans. This strategy should shed light on interactions inaccessible by metabolic oligosaccharide engineering. pubs.acs.org/doi/10.1021/ac… #glycotime

Proud to share this new preprint featuring equal coauthors ⁦Gabby Tender ⁦Judy Shon and⁩ ⁦@KayvonPedram⁩ ⁦(now ⁦HHMI | Janelia⁩). We develop a targeted degradation strategy for pathogenic cancer mucins using engineered microbial mucinases biorxiv.org/content/10.110…

Next Jack Babulic from the Queen's MD/PhD program discussing his work in cell surface engineering to capture glycan/protein interactions

People are asking me about the origins of and key milestones in the timeline of #bioorthogonal chemistry, so here is a quick summary. 1/n

Mini-Me’s for Halloween! 🎃 Great costumes from our #GlycoQueens group. Everyone has imposter syndrome at some point, but maybe I’ll be super productive today!

Had a great time presenting a poster at the #AJM2022 conference in Montreal! Thanks CITAC for the opportunity!

Happy “glycolidays” from the Chantelle Capicciotti group at Queen’s University! Lots of fun making our lab door festive with Marie Boddington Youjin Kim and others! GlycoNet #GlycoQueens

A huge congratulations to Neil Grenade ⌬ on the publication of his most recent paper in #ACSchembiol ACS Publications Bio & Med Chem Content, we are really excited about the apparent convergent evolution of these bacterial alkaloid gene clusters pubs.acs.org/doi/full/10.10…

This is my submission for the AAAS and Science Magazine annual Dance Your PhD contest! The title of the dance is ‘The Importance of Multivalency in Siglec Binding of Sialic Acid’, hope you enjoy! youtu.be/uu0aTtBHtcQ #glycotime #glycoqueens

One-Step Selective Labeling of Native Cell-Surface Sialoglycans by Exogenous α2,8-Sialylation biorxiv.org/cgi/content/sh… #bioRxiv

Congratulations collaborative team lead equally by ⁦Gabby Tender⁩⁦@KayvonPedram⁩ and ⁦Judy Shon⁩, w/coworkers from ⁦Heinz Läubli⁩ and Weaver labs. Mucins drive cancer progression; we drugged them with targeted mucin proteases. nature.com/articles/s4158…

Glyco-Engineering Cell Surfaces by Exo-Enzymatic Installation of GlcNAz and LacNAz Motifs biorxiv.org/cgi/content/sh… #bioRxiv

I’m thrilled one of our first articles is highlighted in a Early Career Innovator issue Bioconjugate Chem! Jack Babulic

Something new for the textbooks, @raflynn5 in collaboration with @GarciaLabMS defines a chemical linkage of glycoRNA as N-glycosylated acp3U!

The plot thickens for #glycoRNA in the immune system! They mediate adhesion of neutrophils to P-selectin on activated endothelium. Given@raflynn5⁩’s previous observation of glycoRNAs binding Siglecs, they could be important immune modulators. cell.com/cell/fulltext/…

Very excited to share that our work at Paszek Lab has finally been published in Nature Materials! Cancer-associated mucins form nanoscale material barriers that resist attack by immune cells, including natural killer cells and CAR-T cells. #glycotime nature.com/articles/s4156…

1/ Thrilled to share an exciting discovery @ ChaoWangBiochem: Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9 #glycotime biorxiv.org/content/10.110…