It's just a platelet -- how complex could it be?!? Spoiler: very. Lucy Zumwinkle Kornblith, MD, FACS beautifully demonstrates how storage affects platelet RNA structure. But HOW?!? She has a hypothesis...You'll hear about it soon #thor2024 #platelets #coag #transfusion #MedX

Exciting news! We've been featured in INSIDEPittResearch. Congratulations! Francis X, Jason Sperry, and Dr. Wisniewski #TraumaCare #Research #PittMed #DoD UPMC LITES Network Pitt Public Health UPMC

Many Congratulations to Joshua Brown on his new role as Statistical Editor for JAMA Surgery #SurgeryResearch #SurgicalExcellence #DataScience #AcademicSurgery University of Pittsburgh UPMC Pitt Critical Care Medicine Pitt General Internal Medicine UPMC Children's Hospital of Pittsburgh Pitt Public Health Pitt Public Health Pitt Health Sciences Pitt Neurosurgery

An analysis was performed using data from two large, double-blinded, randomized prehospital TXA trials. Prehospital TXA is safe & independently associated with a dose-dependent lower 28-day mortality risk & lower 24-hour red cell transfusion requirement. journals.lww.com/jtrauma/fullte…

Bethany Weathersby and Philip Spinella, MD with baby Noah, whose mother was alloimmunized and developed HDFN, opened up the 2024 Symposium on Emergency Transfusion in Females with Childbearing Potential! Allo Hope Foundation #HDFN #alloimmunization #transfusion #MedX

The meeting for public discussion of evidence based recommendations for the treatment of hemorrhagic shock in women and therapies to reduce the risk of HDFN was a huge success! 20 recommendations that will save thousands of lives. Allo Hope Foundation THOR_Network AABB AAST

First pediatric subject enrolled today at Le Bonheur Children's hospital in the first traumatic bleeding platform trial performed. Will LTOWB be superior to components? TXA to placebo? Will find out eventually! THOR_Network Pitt Trauma & Transfusion Medicine Research Center Pitt Surgery

With the beginning of the holiday season underway, LITES wants to express our gratitude for the prehospital, emergency medicine, trauma surgery, and critical care providers who work 24/7 to take care of injured patients! We hope everyone had a safe holiday weekend!

An analysis was performed using data from two large, double-blinded, randomized prehospital TXA trials. Prehospital TXA is safe & independently associated with a dose-dependent lower 28-day mortality risk & lower 24-hour red cell transfusion requirement. journals.lww.com/jtrauma/fullte…

2nd yr AAST ACS fellow Chris Reed PittTrauma/AcuteCare received funding today as PI for his basic science work on Factor IX in #trauma Pitt Trauma & Transfusion Medicine Research Center. Bold statement - NO BETTER fellowship to balance clinical and research excellence in ACS. Fight me Bryan Cotton 😁Jason Sperry

Early cold stored platelet transfusion in TBI patients—compared to room temp platelet transfusion—shows lower rate of neurosurgical operative intervention without increase in adverse events. journals.lww.com/annalsofsurger… Neurotrauma Clinical Trials Center @PittNSGY UPMC Physician Resources Annals of Surgery Pitt Health Sciences

Check out our article in Annals of Surgery! It's not brain surgery - or at least not for TBI pts who received cold stored platelets. 😉 CriSP-TBI found that early CSP transfusion reduced need for operative intervention w/o increase in AE. pubmed.ncbi.nlm.nih.gov/39840438/

Novel phase 2 randomized clinical trial characterizing feasibilty, safety, efficacy of Cold Stored Platelets in TBI LITES Network Pitt Surgery Matthew D. Neal, MD University of Pittsburgh Francis X pubmed.ncbi.nlm.nih.gov/39840438/

New LITES manuscript! Whole blood resus. associated w/ greater achievement of early hemostasis journals.lww.com/jtrauma/fullte… Thank you Francis X Bryan Cotton Jason Sperry Nicholas Namias Denver Health Martin Schreiber Penn Trauma Center UTSW Surgery Pitt Trauma & Transfusion Medicine Research Center !

3 publications in 3 wks; LITES is on a roll! Check out “Adverse Prehosp. Events & Outcomes after TBI" - data on almost 15,000 adults w/ TBI to assess effects of hypoxia, hypotension & hypocarbia on pt. outcomes. Thank you TO-1 contributors & Amelia Maiga, MD, MPH ! jamanetwork.com/journals/jaman…

❇️Best of Trauma❇️ Achieving hemostasis improves coagulation, reduces transfusions, and lowers mortality. Early whole blood resuscitation increases the likelihood and speed of hemostasis within the first 4 hours. @jjasonsperrymd journals.lww.com/jtrauma/fullte…

The NFL Physicians Society has awarded the Arthur C. Rettig Award for Academic Excellence to David Okonkwo—team neurosurgeon for the Pittsburgh Steelers—for his groundbreaking concussion research. bit.ly/4h6FQPi NFL Neurotrauma Clinical Trials Center @PittNSGY Pitt Health Sciences NFL Physicians Society Pittsburgh Steelers UPMC

Next up at #WTA2025 : Pediatric tourniquet use in children associated with improved stability and no adverse events! Pitt Surgery @ChristineLeeper Pitt Pediatric Surgery

Achievement of hemostasis is associated with coagulation, transfusion volumes and mortality benefits. Early whole blood resuscitation is associated with a greater independent odds of achieving hemostasis & at an earlier time point over the first 4 hours. journals.lww.com/jtrauma/fullte…

LITES is at #AAST2025! Investigators and the LITES-curious are welcome to come to our reception tonight (Thursday) – 5-7pm in the Vermont room on the 5th floor. Come visit with Jason Sperry; PACT, PAIN, and CAVALIER staff; and admins. Hope to see you there!