🧬Maximum mammalian lifespan is inversely related to rate of change in methylation at specific DNA regions (bivalent regulatory regions): ROC= 1/maximum lifespan. Several beautiful equations link age-related methylation changes to maximum lifespan. Methylation data bring a dream

5 years ago, on the heels of 28andMe, our team designed a new precision imaging experiment: scanning an individual’s brain throughout her entire pregnancy. We are excited to share that these findings are out today in Nature Neuroscience! nature.com/articles/s4159…

Published today Springer Nature in Nature Methods Genomics 2 Proteins portal G2P: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures nature.com/articles/s4159… /thread

How can we unify genomic data across the scales of biology? By building an AI Virtual Cell!🏗️🔮 In this perspective, we describe what an AI Virtual Cell is, and how to build one: arxiv.org/abs/2409.11654 With Charlotte Bunne Yusuf Roohani Stephen Quake Jure Leskovec Aviv Regev Theofanis Karaletsos

Really impressive paper from Satoshi Koyama, Pradeep Natarajan, and co. looking at rare exome variants in 1.15M (MVP, UKB, AoU) individuals for blood lipids. Fig. 2a provides pretty strong support for including cryptic splice variants (from Illumina's SpliceAI) in gene-based tests.

🪖 My paper on the military in the Mexican 🇲🇽 war on drugs has been published. Contrary to existing literature that suggests the military operates with a war logic, the article reveals a more complex reality: improvisation, human rights violations, disobedience, and more...

Excited to see our AoT paper has been accepted by #EMNLP2024 findings. It introduces a new LLM reasoning paradigm that enforces different abstraction levels, significantly improving LLMs' reasoning performance. The code and data are coming out soon.✌️ 📰arxiv.org/abs/2406.12442

All major neural networks, in one chart: bit.ly/2HB7tl9 v/The Asimov Institute

Para explicar la interacción de factores genéticos y ambientales en algunas de las enfermedades psiquiátricas, es muy útil la analogía de la jarra que rebosa por la mezcla de factores genéticos y ambientales en distintas proporciones. genotipia.com/genetica-en-ps…

Combining networks and polygenic scores, this study shows polygenic scores for psychopathology traits associate with a restricted number of trait-relevant and cross-trait symptoms, replicated in an independent sample with preregistered analyses. ja.ma/4eAd5dd

Your biological age should NOT be ONE number. Introducing Ageome: our new framework that measures aging across thousands of molecular pathways simultaneously 🧬. Ageome challenges the single-number paradigm of biological age, offering a high-dimensional view of aging across

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Inferring human prehistory from genetic data [this thread] 3.4: Ancient DNA [next thread] web.stanford.edu/group/pritchar…

Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human population structure and history: 3.3: Human prehistory [separate thread] 3.4: Ancient DNA: a genetic time capsule [this thread] web.stanford.edu/group/pritchar…

New paper alert!🚨In our new Nature Mental Health paper, we analyse over 350 million patient encounters across 14 years in Norwegian primary care, and find that 1 out of every 9 visits concerns mental health conditions!🧵Paper: nature.com/articles/s4422…

The Brazilian National Cancer Institute (INCA), in collaboration with Wellcome Connecting Science Learning and Training (Wellcome Connecting Science), is conducting an IMPORTANT survey to assess the current landscape, capacity, and infrastructure for #singlecell and #spatialtranscriptomics research in #LatinAmerica.

What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too? And why should we care? A 🧵 on our paper on the Nobel Laureates. A teaser: the income distribution of the laureates' fathers.1/N

Check out two great #WCPG2024 talks today! Brenda Cabrera Mendoza will present her work on #equitable collaborations among low-, middle-, and high-income countries. Elena Friligkou will describe her efforts on understanding #anxiety using genetic information from >1.2M participants

Super proud of my trainees for doing an amazing job at presenting their findings at #WCPG2024 ISPG in Singapore! #MontalvoOrtizlab Yale Psychiatry

Hello, everyone! Over the next two weeks, I'd like to invite you to learn what is being done to understand psychiatric disorders in Latin American populations. If you're interested, join us! LAGC-PsychiatricGenetics #latinamerican #genetics

Hola a todos ! Durante las próximas dos semanas, me gustaría invitarles a descubrir lo que se está haciendo para comprender las enfermedades psiquiátricas en las poblaciones latinoamericanas. Si te interesa, ¡únete a nosotros! LAGC-PsychiatricGenetics