Scripps Research’s Prof. Jin-Quan Yu cracked one of the most ubiquitous bonds on the planet, the C-H bond, opening up a universe of new molecules in manufacturing & pharmaceutical design. Read about Yu’s winding path from rural China to chemistry fame: magazine.scripps.edu/profiles/2022/…

Don’t forget to register for our upcoming Desktop Lectureship Seminar on 21 July at 13:00 BST ⏳ This free event will feature talks from the 2021 and 2022 NPR Lectureship winners Hans Renata Hans Renata and Jinghan Gui Gui Lab Register here today 🔗 bit.ly/3Ikajda

Check out our recent syntheses of bufospirostenin A and ophiopogonol A in only seven steps from inexpensive starting materials just out in J. Am. Chem. Soc. . Great collaboration with Hong group from Zhejiang University for computational studies: pubs.acs.org/doi/10.1021/ja…

Fantastic news! Congrats Phil!

Just now in #OL, Gui Lab et al. report the first synthesis of the phenolic steroid myrmenaphthol A, featuring a Baran decarboxylative coupling and a Friedel–Crafts cyclization/aromatization cascade. Check it all out here pubs.acs.org/doi/10.1021/ac…

Today we report in ChemRxiv a scalable solution to the total synthesis (and structural reassignment) of the Portimines (bit.ly/3iJ61DT). In collaboration with Chris Parker and Luke Lairson the remarkable biological activity of this natural product family was revealed

Modern alchemy appearing today in Science Magazine : science.org/doi/10.1126/sc… Commentary (thank you Prof. Ye!): science.org/doi/10.1126/sc…

Our 13-step synthesis of the rearranged steroid phomarol, which features a biomimetic, stereospecific SN2’ cyclization and a convergent fragment-coupling strategy, is now out in J. Am. Chem. Soc. : pubs.acs.org/doi/10.1021/ja…

Our 15-step, bioinspired two-phase synthesis of gibbosterol A, featuring a Ru-catalyzed endoperoxide fragmentation and a series of selective redox transformations, is out in JACS Au : pubs.acs.org/doi/10.1021/ja…

Check out our latest review on the efficient syntheses of steroid, terpenoid and alkaloid natural products by a skeletal reorganization strategy, out now in Nat. Prod. Reports : rsc.li/3UpPp4s

Our first work on the chemoenzymatic synthesis: using KSH enzyme as the biocatalyst enables the steroidal 9α-hydroxylation and B-ring fragmentation cascade to give 9,10-secosteroids. Great collaboration with Prof. Wen Liu at SIOC. Out now in Angewandte Chemie : bit.ly/3UHm5q8

Our latest synthesis of the 18,22-cyclosterols aspersteroids A and B, which features an interesting radical relay cyclization and a Ti(III)-mediated diastereoselective epoxide reduction, is now out in J. Am. Chem. Soc.: bit.ly/3IiAYYv

Published today in Science Magazine : science.org/doi/epdf/10.11…

The final version of this work was published in Nature Chemistry : nature.com/articles/s4155…

You don't need to be a chemist to make C(sp3)-C(sp2) bonds... (video by Tamara E)

Our synthesis of the bisnortriterpenoid rubriflordilactone B, which features a [2,3]-Wittig−Still rearrangement, a Friedel−Crafts cyclization and an E1cB reaction/transesterification/oxa-Michael addition cascade, is now out in J. Am. Chem. Soc. : bit.ly/430IyCx

Our recent work in steroid synthesis, which features a tandem Negishi/Heck cross-coupling and a Baran reductive olefin coupling (BROC), is now out in J. Am. Chem. Soc.: pubs.acs.org/doi/10.1021/ja…

Check out our review on the emerging methods and strategies for the efficient synthesis of steroid natural products in Chem. Soc. Rev. Thanks Yu Wang for writing this review: bit.ly/45Xfrl0

Our syntheses of harziane diterpenoids (including harziandione and harzianone) are now out in J. Am. Chem. Soc. . This work highlights again the power of Baran reductive olefin coupling (BROC) in building sterically hindered C−C bonds: pubs.acs.org/doi/10.1021/ja…