Inflammation activates key protein linked to Parkinson’s and Crohn’s diseases ppu.mrc.ac.uk/news/inflammat…

Multiscale guidance of AlphaFold3 with heterogeneous cryo-EM data １．The paper introduces CryoBoltz, a novel method that combines cryo-EM density maps with pretrained protein structure prediction models, specifically AlphaFold3, to generate accurate atomic models of dynamic

AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry １．This study utilizes AlphaFold models to predict the structures of host-pathogen protein-protein interactions (PPIs), shedding light on the prevalence and

Balancing Speed and Precision in Protein Folding: A Comparison of AlphaFold2, ESMFold, and OmegaFold １．This study benchmarks AlphaFold2, ESMFold, and OmegaFold using over 1,300 truly novel protein structures from the PDB (2022–2024), none of which were in any tool’s training

This is useful for connecting tag within proteins, not just at their C- or N-terminus

Looking for a deep dive into 2D classification in #cryoEM? These recent guide pages cover practical aspects & parameter choices when running these jobs in #CryoSPARC, along with the theory behind expectation maximization: guide.cryosparc.com/processing-dat… and guide.cryosparc.com/expectation-ma…

Exciting findings from Jun Liu Lab #postdoc Yue Jian Yale School of Medicine Architecture and activation of the Legionella Dot/Icm type IVB secretion machine #cryoEM #cryoET #Legionella biorxiv.org/content/10.110…

Congratulations to Prof. Rotem Sorek of the Department of Molecular Genetics, upon being awarded the 2025 Robert Koch Award Sorek Lab

New study shows how bacteria evolved powered-up propellers imperial.ac.uk/news/265473/ne… ... nature.com/articles/s4156…

Our Molecular Cell Spotlight on the Hailong anti-phage system from the Kranzusch lab! This defense uses "ssDNA tripwires" to trigger toxic ion channels 🧬⚡☠️ Fun write with Johannes Kühn!!

Researchers at #UTSW have identified over 200 strategies used by bacteria to fight off viral infections, or bacteriophages. Find out how the team’s findings could eventually help improve treatments for antibiotic-resistant bacterial infections. bit.ly/3H7CL5W #utswmed

We made it on the cover! So proud of the team 🎉 You can use BioEmu for free now to get AI predictions for the entire distribution of conformations a protein can take: github.com/microsoft/bioe…

Out Now! Characterization of an amyloid-based antiphage defence system in Escherichia coli bit.ly/4lrUAuc #EscherichiaColi #Microbiology #Amyloid

New preprint shows that DALI, TM-align and Foldseek overestimate protein structure alignment significance by 5-6 orders of magnitude biorxiv.org/content/10.110…](biorxiv.org/content/10.110…

New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07

Q score

Allosteric mechanisms that convey amino acid sufficiency to GATOR2 and the ensuing structural changes that lead to mTORC1 activation nature nature.com/articles/s4158…

The meeting announced the establishment of the Alliance of Open Life Science by 15 institutions. Westlake University President Yigong Shi (co-chair) introduced the Vita series of high-impact scientific journals. This groundbreaking initiative calls on the international life

New preprint! We report the largest plant resistosome ever described. We revealed the wheat NLR WAI3, a member from the mysterious CCG10-NLR clade, forms an unprecedented octameric assembly with a unique channel architecture. And the well-known RPS2 might work the same way!