Congrats to Biozentrum, University of Basel Swiss National Science Foundation Ambizione Group Leader Florent Waltz on this stunning study🤩 of respirasome structure & organization inside native cells! It's amazing how quickly in situ #cryoET is advancing. Read Florent's thread🧵 for the high-resolution details🔎🦠 #TeamTomo

#Glycotime I am hiring a Co-op (June -December). If you are interested in developing MS based O-glycoproteomics workflows, Native and CDMS please apply below! careers.regeneron.com/en/jobs/r34682… via @regeneron

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. Bruno Correia Sergey Ovchinnikov biorxiv.org/content/10.110…

The future of integrated structural biology cell.com/structure/full…

fantastic usage of #MolecularNodes

Inspired by the #NobelPrize for #proteinstructure prediction and design and want to dive into the field? Our Rosetta Commons code school video playlist will teach you all the tools - Rosetta, AlphaFold, RFDiffusion, and more! #ProteinDesign #DavidBaker youtube.com/playlist?list=…

Thrilled to see my PhD work published! 🪇 Check out GPMelt, our new framework for uncovering the dark meltome of TPP datasets Savitski Lab @MagnusRattray. Discover how we’re pushing the boundaries of thermal proteome profiling! See the implementation: git.embl.de/grp-savitski/g…

Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out Nature Biotechnology ! Read here👉: doi.org/10.1038/s41587… 🔬 Highlights: - Uses an experimental library of peptide markers integrated with a structural proteomics workflow. -

Excited to report that protocol for DNA-encoded, Liquid Glycan Array (LiGA) is out in Nature Protocols. In addition to the protocol, we report how the expression level of Siglecs and cell types affect their ability to bind to LiGA. nature.com/articles/s4159…

I am very pleased the first work of Jo @judernatz is now out on bioRxiv showing how cargo is transported during spermiogenesis biorxiv.org/content/10.110…

Very excited about this joint work with Saez-Rodriguez Group !

The Liquid Lectin Array (LiLA) paper is out in CellChemicalBiology. Congratulations to Guilherme Meira Lima for this amazing publication and it was my privilege to play a [small] part in this project. #Siglec #Glycotime #Phage #Glycans cell.com/cell-chemical-…

Even more reasons to avoid BioRender

Excited to receive a poster prize at #SSP2024! Big thanks to SSP 2024 for organizing a great conference.

Kicking off 2025 with a campaign to get 3D-SNFG implemented in ChimeraX by the kind folk ChimeraX (bsky: chimerax.ucsf.edu) Who’s with me?! #glycotime academic.oup.com/glycob/article…

We sequenced the anti-RSV-F antibody 131-2a by mass spec, then mapped its epitope by cryoEM. It's widely used to study the antigenic landscape of F, but its seq wasn't known. Check it out in our new preprint and find it on Addgene biorxiv.org/content/10.110… addgene.org/Joost_Snijder/

Check out our recent publication Molecular & Cellular Proteomics on the hyper-permeability of the synovial compartment for plasma proteins in #rheumatoidarthritis patients! Using a three-level analysis we compared the plasma proteome and the (auto)antibody repertoires between plasma and SF of RA.

Want to know how the ligands interact with proteins beyond model human cell lines? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within 2 hours! biorxiv.org/content/10.110…

GoGoGoGoGoGoGoMartini3 now finally published! nature.com/articles/s4146…

The ChimeraX 1.10 release candidate and daily builds can predict small complexes of proteins, nucleic acids and small molecules using Boltz on your Mac, Windows or Linux computer. rbvi.ucsf.edu/chimerax/data/…