bioRxiv In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumor Julia Carnevale UC San Francisco Gladstone Institutes biorxiv.org/content/10.110…

#ICYMI: Dr. Haley Newman receives Hope On Wheels Young Investigator Grant that will support research on risk predication models for T-cell malignancies. Learn more in this Action News on 6abc report: ms.spr.ly/6012sSuru.

Long-term outcomes of genome-edited “universal” CAR19 T cells for relapsed/refractory B-ALL at a single pediatric center ow.ly/bTS650X1vxT #clinicaltrialsandobservations #genetherapy #lymphoidneoplasia

This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease science.org/content/articl… washingtonpost.com/health/2025/09… economist.com/science-and-te…

Rob Manguso Brian Miller Dr Marcela Maus nature Mass General Brigham Research Broad Institute Congrats Rob, beautiful study!

Huge shoutout to every NIH official grinding non-stop to support researchers and pushing through to meet that Sept 30 award deadline to ensure 100% of the funds are sent. You're the heroes keeping biomedical research alive. Unfortunately politicians are not as good as you are.

Today is the last day of Childhood Cancer Awareness month. I haven't been able to find the words to do it justice--I'm not sure there are any. The world has told us pediatric cancer is "rare", in part to justify its low budget towards this research, but it's a lie.

Well done to Claire Roddie and team for this amazing work. Many take home messages from this work -Lymphodepletion is essential for CAR-T to work -Repeat doses don't seem to work here, but more work is needed HCC_UCLH ashpublications.org/blood/article-…

The description of regulatory T cells and connection to FoxP3 is a beautiful story for #Science and the #NobelPrize

We're thrilled to once again be ranked among the very best in the nation for Pediatric Cancer by U.S. News & World Report!

In a national cohort of veterans, the 2024–2025 Covid-19 vaccine was linked to reduced risks of emergency department visits, hospitalizations, and deaths from Covid-19 NEJM Ziyad Al-Aly, MD nejm.org/doi/full/10.10…

Our new, comprehensive review on CAR T cell persistence is officially published in Cell Trends in Cancer. Fantastic work from lead authors Kat Mueller, PhD Jeremy Grenier MD PhD. Link to the full article: cell.com/trends/cancer/…

#genetherapy for #hemophilia can be life changing. Proud to offer this transformative treatment at Children's Hospital Gene therapy changed the life of a South Jersey man with hemophilia | PhillyVoice phillyvoice.com/gene-therapy-h…

#Cellcoast25 Moffitt Cancer Center expert presentation by bshah describing the move to treat B-ALL with car t consolidation in frontline. Can we shorten therapy and eliminate the high relapse rate in adults by early CAR T? Looking v. promising.

Tumor-on-chip models of CAR-T cell therapy Nature Biotechnology nature.com/articles/s4158… nature.com/articles/s4158… sciencedirect.com/science/articl… Cell Stem Cell

How do mRNA vaccines help fight cancer? A @nature publication today tells the story, one with big implications, as reviewed here MD Anderson Cancer Center Steven H. Lin Adam Grippin erictopol.substack.com/p/how-mrna-vac…

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxic effects. Full study results: nej.md/42u4eWF

👇Fascinating observation. Raises important questions, including whether the Moderna adjuvant vaccine study result in melanoma (Keynote-942) was attributable to *any* vaccine encoded epitopes. FYI: Neither this nor phase 3 (NCT05933577) has empty vector control. FDA

Faculty position opening in our pediatric ‘Transplantation and Cellular Therapy’ Service ⁦Memorial Sloan Kettering Cancer Center⁩ Don’t hesitate to reach out to me for questions!! msk.wd1.myworkdayjobs.com/en-US/MSKCC_Ca…

This is a perfect sentiment - when you can't bear to see it anymore, that's how you know it's ready to go!