Motivated by the obscenely high cost of #COVID19 testing reagents, we developed #BEARmix🐻 - an inexpensive, open-source master mix for 1-step RT-qPCR! It can reliably detect 10 RNA copies/rxn and can be made by any lab equipped for prot purif. Protocol👉 gitlab.com/tjian-darzacq-…

On Feb 29, using the genetic sequence of the first community case of #COVID19 in Washington State, I made the claim that the Washington State outbreak descended directly from the Jan 15 arrival of the WA1 case with direct travel history to Wuhan. 1/18 x.com/trvrb/status/1…

So proud of Karen Miga Sergey Koren and our entire #T2T consortium for the first-ever "Telomere-to-telomere assembly of a complete human X chromosome"! Fills all reference gaps and reveals methylation patterns of satellite arrays nature.com/articles/s4158…

NEW—Observations of the global epidemiology of #COVID19 from the prepandemic period using web-based surveillance: a cross-sectional analysis CDC The Lancet Infectious Diseases hubs.ly/H0t3HZ80

How gene transcription works. DNA to RNA: #biology by D. Berry

Thrilled to share our latest preprint describing a potential new target in the pathobiology of #PAH! 🙌 Huge thanks to the amazing Bill Nichols & Lisa Martin at Cincinnati Children's, Harm Jan Bogaard & team Amsterdam UMC & the PCCM Div University of Cincinnati! #genomics #PH🚀 biorxiv.org/content/10.110…

Stockpiled A(H5N1) #influenza #vaccines from the mid-2000s stimulate antibodies that cross-react with current strains — supporting investment in vaccine stockpiling for pandemic preparedness. News & Views from Richard Webby St. Jude Research nature.com/articles/s4159…

Can portable ultra-low-field MRI revolutionize stroke detection in ECMO patients? The multicenter SAFE MRI ECMO study shows it's safe and more sensitive to detect ischemic stroke than CT H Alex Choi Errol L. Bush, MD, FACS Bindu Akkanti, MD. Haris Sair Kha Dinh Sung-Min Cho ahajournals.org/doi/abs/10.116…

🚨 Calling all experts! 🚨 We're looking for volunteers to moderate exciting sessions for the ATS PC Assembly assembly #ATS2025 in SF! 🌉 It's your chance to get involved and lead impactful discussions. Ready to join? Sign up here: 🔗 conference.thoracic.org/speakers/moder… #PH #PAH #PVD #RV #PE #CTEPH

🌟 Calling all aspiring pulmonary specialists! 🌟 Join us for an awesome seminar on "Building a Pulmonary Career as an Immigrant in the USA" 🇺🇸. Learn about navigating challenges and breaking barriers in pulmonary vascular disease! 🗓️ Friday 12/13/24 🔗 site.thoracic.org/events/a-caree…

Editorial: Could Lentivirus Overcome the AAV Gene-Therapy Challenges in Hemophilia A? nej.md/4fOF35T

If you read one science thread today, make it this one! Now in nature, the latest work from #CZBiohubSF Investigator Michael Fischbach's team could open the door to receiving vaccines as a skin cream. Also see great coverage by Stanford Medicine's Bruce Goldman: med.stanford.edu/news/all-news/…

New updates at LungMAP.net! Check our new collection of ShinyCell and CellxGene viewers, including post-viral lung regeneration (MorriseyLab), Bronchopulmonary Dysplasia (Xin Sun Lab and Jen Srygley Sucre) and Interstitial Lung Disease subtypes (Nick Banovich), now live.

Excited to share our latest article. 7 years ago my then 9 year old son was diagnosed with K210del DCM. With the help of my colleagues Joseph C Wu, MD, PhD, Sakthivel Sadayappan, PhD, MBA and Enzo Porrello we identified an FDA approved drug that corrects the mutation. JCI - An FDA-approved drug

Big congratulations 🎉 to Mark Nicolls, MD and his phenomenal team Stanford University on this cutting-edge study! Another masterclass in translational science—continuously redefining what's possible in #PAH research! biorxiv.org/content/10.110…

What does it really take to move science from the bench to the bedside? 🧬🚨🚨🚨 Join us at #ATS2025 for a behind-the-scenes look at the hurdles, pivots, and breakthroughs that shape translational research. Don’t miss the stories behind the science. ats2025.d365.events/directory/sess…

Dosa: A method to covalently barcode proteinsfor high throughput biochemistry biorxiv.org/content/10.110… #biorxiv_genomic

Tylenol, or paracetamol, has been used to treat common pains and fevers since 1893, and is one of the safest drugs around go.nature.com/3W6aHU8

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting survival • Lifespan PRS predicts survival better

Short Report by G Scharf et al. (UC College of Medicine Saint Joseph Hospital Denver Cystic Fibrosis Foundation) #TGFβ induces excessive #pulmonary #IL6secretion in #cysticfibrosis via #PI3K ow.ly/9iBn50X9HOa