AI has dreamt up a blizzard of new proteins. Do any of them actually work? go.nature.com/48oAeNX

OUT NOW in nature: A bacterial immunity protein directly senses two disparate phage proteins By Tong Zhang, Abel Garcia-Pino, Michael Laub & colleagues. Michael Laub nature.com/articles/s4158…

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at Institut Pasteur, since 1887 . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.

DENSE is out! Mine your genome and highlight its de novo genes :D

You still have a couple of weeks to submit an abstract for our next #LEGO meeting day in Paris! gt-lego.cnrs.fr/animation/lego…

Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman go.nature.com/4hp4UCP

Timescales in Cell Biology

This is great! NIAID News have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov

🚨 New preprint alert! 🚨 We're excited to share our latest work: "Towards a complete phage tail fiber structure atlas" 🦠🔬 of first author Victor Klein-Sousa We developed #RBPseg for segmenting and merging phage tail fibers using structural prediction tools. tinyurl.com/58cn2ew7

This could be a good time to remind those that may have not seen it before, that the reactome database at EMBL-EBI also has a library of open access icons reactome.org/icon-lib

Come listen to my boss yap.

My guidelines for exploratory data analysis

Remember Golden Gate Claude? Etowah Adams and I have been working on applying the same mechanistic interpretability techniques to protein language models. We found lots of features and they’re... pretty weird? 🧵

Protenix - Yet another reproduction of AF3 github.com/bytedance/Prot…

Today we report in Nature Biotechnology a system for the laboratory evolution of engineered virus-like particles (eVLPs) that enables the discovery of eVLP variants with desired properties, including improved production and delivery potency. 1/13 PDF: drive.google.com/file/d/1E6Nr86…

The Evo 1 paper is now published!

A couple years ago I tried to get structural biology people to migrate to 🦋 by handing out invites which were in short supply. It worked for a bit but there wasn't much engagement there. Everything has changed in the last week. So please join us there.

We’re so exited about the community’s use of Boltz-1 already! We’ve just released a new update to of the Boltz-1 repo, which now automatically generates MSA’s for users in seconds using the amazing Colabfold MMseqs server. Test it out here: github.com/jwohlwend/boltz

L’I2BC quitte Twitter. Retrouvez-nous sur Bluesky @i2bcparissaclay.bsky.social pour suivre nos actualités scientifiques CEA Paris-Saclay,CNRS Biologie,Université Paris-Saclay

🧬 Comprendre les interactions protéine-ARN pour ouvrir la voie à de nouvelles approches thérapeutiques. Le projet ESPRINet, mené par des scientifiques de l’I2BC Paris-Saclay, vise à élucider les mécanismes moléculaires sous-jacents de ces interactions. ▶ lejournal.cnrs.fr/nos-blogs/focu…