Biorender has 225 employees??

Before you talk to me, ask yourself: would Van Gogh have wanted to hear the opinion of someone who's never created a masterpiece?

We're going to see a situation where a lot of life science PIs will come to the bfx core like: "I vibe coded this analysis but it isn't working right. I need you to fix it." The only appropriate response to this is "Fuck off."

Hey Delta It's cool to depart early, but maybe not when people are trying to make a connection. Don't you track these things?

Gave a talk today and had someone who was actually engaged. I thanked him later and he said he did stand up comedy and remembers being distracted by people talking and texting and shit so he doesn't do that. Something to consider.

ok this is sloppy but i still feel bad for people whose figures are ruined by overzealous grammar checks

Am I the only one who doesn't want their smoke detectors talking to each other? I don't need them spreading rumors about fires like they're in grade school. How would I even know who started the lie?

The choice of reference genome is important for reproducibility and reducing artefacts but if the primary endpoint of your experiment only achieves significance with one particular reference you may have a problem with robustness

Learned about an interesting portal spin-off from Fred Hutch called Cirro.bio. Immediately added it to the "List of cloud genomics companies" biostars.org/p/86463/

Baykal et al "Assessing genomic reproducibility of read alignment tools" - one of the few papers I've seen that study tool robustness biorxiv.org/content/10.110…

How many hours a weekend do you spend futzing around with weedwacker string?

Palantir got most of its early funding helping the CIA and NSA with terrorism and surveillance but their real strength is in ontologies. Ontologies come from the crunchiest hippie humanist corners of computer and information science, really library science.

I spent the first 27 years of my career breaking down the most trivial problems for computers to digest and the last month with Claude/Cursor asking "how did you know that's exactly what I wanted?"

I remember when Bill Atkinson showed off HyperCard to the Stanford Macintosh Users Group (SMUG). People were literally gasping.

Oh please. They reboot brains for the sheer thrill of it.

What startups are focused strictly on reducing friction in getting permissions to random shit for developers?

My favorite GWAS trait is "perceived unattractiveness to mosquitos"