🧬🔍Ever wondered which transcription factors control the expression of your favorite gene? We've got you covered, presenting a rich repository on TFs binding and function at the gene level! 📚💡 Dive into the exciting details here: biorxiv.org/content/10.110…

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair dlvr.it/TJMvqj

Review: Hyrien et al. discuss the nature of the initiation sites of DNA replication, amalgamating findings from various advanced DNA replication mapping techniques in order to build a more cohesive model of DNA replication initiation. Learn more here: ➡️ tinyurl.com/gd352227

SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis dlvr.it/TJR6Ql

RNA polymerase II processing facilitates DNA repair and prevents DNA damage-induced neuronal and developmental failure biorxiv.org/content/10.110… #biorxiv_molbio

Interested in these or related topics and looking for (or know somebody looking for) a PhD position? We have openings @uzh_en and an approaching application deadline Life Science Zurich: lifescience-graduateschool.uzh.ch/en.html. Please retweet. #PhDLife #LifeScience #Switzerland

Thrilled to share our latest work at Science Advances. Great collab with Costanzo, Masson, Freire and Reyes labs. HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances science.org/doi/10.1126/sc…

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

Vandaag is dag 100 van het tweede presidentschap van Trump. Al 99 dagen houd ik dagelijks bij wat al zijn besluiten zijn en wat de impact daarvan is. Al die besluiten blijken onder 14 thema's te kunnen worden geschaard. Tijd voor een draadje met de highlights daarvan:

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! academic.oup.com/nar/article/53… 1/3

Structure and function of histone chaperones in replication-coupled chromatin assembly sciencedirect.com/science/articl…

The Barnes Lab's first preprint is up :) biorxiv.org/content/10.110…

Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance dlvr.it/TKqSww

Thanks Dr. Basto for an interesting talk. Social DNAing will welcome another old friend - Dr. Philippe Pasero this week to discuss replication forks. Sign up at cancer.columbia.edu/research/progr…

Happy to share our latest paper on cell phase specific mechanisms of micronuclei formation. Thanks to Fondazione AIRC per la ricerca sul cancro and Università di Bologna. cell.com/cell-reports/f…

🛟Wow cyclic peptides are cool! Excited to share a new publication on "Potent Cyclic Peptide Inhibitors Disrupt the FANCM–RMI Interaction". Work led by @yuhenglau to which we contributed structures and ideas. The top hits mimic native MM2...but in reverse! pubs.acs.org/doi/10.1021/ac…

Online Now: The NAMPT enzyme employs a switch that directly senses AMP/ATP and regulates cellular responses to energy stress dlvr.it/TLJ7D5

Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to Thomas Clarke for leading the project! nature.com/articles/s4155…

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975

Online Now: The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks dlvr.it/TLZkmH