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Improving ALS detection and cognitive impairment stratification with attention-enhanced deep learning models GregoryLab nature.com/articles/s4159…

🚀𝐕𝐢𝐬𝐢𝐨𝐧-𝐭𝐫𝐚𝐧𝐬𝐟𝐨𝐫𝐦𝐬-𝐛𝐚𝐬𝐞𝐝 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐮𝐧𝐯𝐞𝐢𝐥𝐬 𝐡𝐢𝐝𝐝𝐞𝐧 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬! 🧵 Thread on 𝘕𝘖𝘝𝘈 (𝘕𝘦𝘶𝘳𝘰𝘯𝘢𝘭 𝘖𝘳𝘨𝘢𝘯𝘦𝘭𝘭𝘰𝘮𝘪𝘤𝘴 𝘝𝘪𝘴𝘪𝘰𝘯 𝘈𝘵𝘭𝘢𝘴)🎗️ our deep-learning model trained with

Excited to share our preprint: "𝐎𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐨𝐦𝐢𝐜𝐬: 𝐀𝐈-𝐝𝐫𝐢𝐯𝐞𝐧 𝐝𝐞𝐞𝐩 𝐨𝐫𝐠𝐚𝐧𝐞𝐥𝐥𝐚𝐫 𝐩𝐡𝐞𝐧𝐨𝐭𝐲𝐩𝐢𝐧𝐠 𝐫𝐞𝐯𝐞𝐚𝐥𝐬 𝐧𝐨𝐯𝐞𝐥 𝐀𝐋𝐒 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐢𝐧 𝐡𝐮𝐦𝐚𝐧 𝐧𝐞𝐮𝐫𝐨𝐧𝐬"

Prof. Prof Jenna Gregory 's talk at LifeArc 's recent Translational Science Summit on MND & Rare Dementias is now online. Jenna shares a compelling vision for early diagnosis & prevention of #ALS/#MND. youtube.com/watch?v=sdQzdC…

Take a look at our recent Lancet Neurology review. Amyotrophic lateral sclerosis caused by TARDBP mutations: sciencedirect.com/science/articl… It’s been a huge privilege working with this incredible writing team and we hope you enjoy reading it. ⭐️🤩🤓🤩⭐️

Clinical Safety and Preliminary Efficacy of Regulatory T Cells for ALS | NEJM Evidence evidence.nejm.org/doi/full/10.10…

🤓Check out our new preprint🤓 Here we examine pre-symptomatic peripheral non-CNS (archival) tissues using an RNA aptamer that detects TDP-43 pathology. We show peripheral pathology that precedes motor symptoms by 1-14 years.

Check out our review on TARDBP ALS and TDP-43 proteinopathy Rickie Patani The Lancet Neurology The Francis Crick Institute PataniLab jemeen sreedharan Martina Hallegger Raphaëlle Luisier Hilal Lashuel Prof Jenna Gregory. Thank you to all our co-authors! sciencedirect.com/science/articl…

We are excited to join MND Association and My Name'5 Doddie Foundation today at #BNAFest2025! The session will spotlight the cutting-edge work happening across the UK to better understand, diagnose, and ultimately treat motor neuron disease (MND) 💙 Read more: lnkd.in/eb5f7sYS

A productive Monday at our Scientific Advisory Meeting 🔬 These meetings bring together some of the UK's top MND researchers, as well as people living with MND, to share knowledge, enable critical assessment of the latest trends and help us keep pace with advances in research 🤝

Such a pleasure to co-organise the FTDUK annual meeting in Edinburgh this week. Highlights included Holly Spence presenting her work on adapting imaging modalities to improve precision medicine in #ALS and #FTD and a tour of the National Robotarium

Well deserved Alex Cammack 👏🏻

Researchers, clinicians, advocates, and people living with ALS from over 30 countries gathered at the 2025 Target ALS Annual Meeting—sharing bold ideas, collaborating and driving momentum towards breakthroughs. Sign up to learn more and see what's ahead: bit.ly/3GGRGTT

Excellent talk by Lizzie Lizzie Dellar on UCHL1 in asymptomatic C9orf72 HRE carriers at the FTD UK meeting in Edinburgh last week #ALS #FTD

We are excited to be here in Turin for #ENCALS2025! Come and check out our posters later today - see below for our presenters and poster numbers #MND #ALS

Great to visit Edinburgh last week to share our work on #UCHL1 and catch up with colleagues working across both #FTD and #ALS

#ENCALS2025 in Turin is over, but we’ve had an amazing time presenting our team’s (GregoryLab) work as posters and oral presentations. A wonderful demonstration of the excellent translational neuroscience research going on University of Aberdeen. Can’t wait for Madrid next year! ⭐️🤩⭐️

Delighted to be able to contribute to this important piece of work driven by Salim Megat, Raphaelle Cassel, and Luc Dupuis demonstrating the significance of FUS mislocalisation outside of FUS mutation carriers in ALS medrxiv.org/content/10.110… GregoryLab Fergal Waldron

FUS implicated in cognitive & behavioral dysfunction in ALS, nominating FUS mislocalization & its downstream gene network as therapeutic targets. Delighted to contribute with Prof Jenna Gregory - work driven by salim megat, Raphaelle Cassel & Luc Dupuis. medrxiv.org/content/10.110…

At our Annual Meeting, Dr. Jenna Gregory shared how her team is bringing oncology-style precision to ALS—studying how T cells behave differently with #ALS. Her findings, through research we fund, offer clues for better treatment. Sign up to learn more: bit.ly/3GGRGTT