Our VIP Review published in ChemBioChem …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

Our method for efficient double labeling of mRNA and its diverse in vitro and in vivo applications published in Nucleic Acids Research. I am very proud of this work. academic.oup.com/nar/advance-ar…

Fundacja na rzecz Nauki Polskiej i Nagrody FNP mają 30 lat! Gratulujemy tegorocznym laureatom z Polska Akademia Nauk i Uniwersytet Warszawski i kontynuujemy naszą misję wspierania najlepszej nauki w Polsce. #30latFNP, #NagrodyFNP, szczegóły na stronie:👉bit.ly/3IwML4j

#MDPIPharmaceutics 📗 "Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation" by Radoslaw Wojcik et al. Full paper at：mdpi.com/1999-4923/13/1…

We have #RecentlyPublished an #aricle by Dorota Kubacka and her associates: #Substrate-Based Design of Cytosolic Nucleotidase IIIB #Inhibitors and #Structural Insights into Inhibition Mechanism Full text is available at: 👉mdpi.com/1424-8247/15/5… Uniwersytet Warszawski Max Planck Institute of Biochemistry (MPIB)

We are looking for post-docs interested in working on novel therapeutically relevant mRNA modifications in our chembiobiochem.com group. Retweets appreciated! cent.uw.edu.pl/en/career/post…

Chemically Modified Poly(A) Analogs Targeting PABP: Structure Activity Relationship and Translation Inhibitory Properties (Jemielity, Kowalska et al.) Jacek Jemielity Joanna Kowalska #OpenAccess onlinelibrary.wiley.com/doi/10.1002/ch…

The first nucleosides for the SuFex reaction – useful tools in chemical biology and drug discovery published in #OL by Jacek Jemielity. Learn more here: pubs.acs.org/doi/10.1021/ac…

We are looking for two post-docs to work on an exciting project aimed at finding new ways to improve therapeutic mRNAs! If you would like to join our chembiobiochem.com group, please apply. euraxess.ec.europa.eu/jobs/814952 Retweets appreciated. Post-doc Positions PostdocJobs.com Jacek Jemielity

We published in JOC a procedure for modifying commercially available building blocks for synthesis of oligonucleotides. The method provides quick access to tools for studying post-transcriptional modification of RNA. Joanna Kowalska, Uniwersytet Warszawski J Org Chem/Org Lett pubs.acs.org/doi/10.1021/ac…

The recruitment is open one more week. Don't forget to apply!

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion NAR academic.oup.com/nar/advance-ar…

Today in ChemRxiv (bit.ly/3ic6OMI): Democratized access to stereo pure thioisosteres of life's building blocks with promising translational potential in medicine. New reagents and a completely different strategy coupled to some amazing collaborators enabled this study.

Thanks Phil and the team for a great collaboration! Joanna Kowalska Baran Lab

Proud of exploRNA team

Thank you Jeff Mugridge for your visit and sharing with us the great science!

A summary of our research on therapeutic mRNA published in Accounts of Chemical Research. Topics very timely lately :). Congratulations to Katalin Kariko and The Drew Weissman Lab !!! pubs.acs.org/doi/10.1021/ac… Uniwersytet Warszawski Joanna Kowalska

A good home for our joint research! Thank you again for the exciting collaboration! Nature Chemistry Baran Lab Uniwersytet Warszawski Joanna Kowalska

Biology-inspired modification of the 5' end of mRNA with high therapeutic potential. Probably the most important research in my life so far.

New Cover from Ella Maru Studio! Advanced mRNA Cap✊ This paper describes AvantCap - a chemical modification of messenger RNA 5' end that confers superior translational properties to mRNA. The design of AvantCap was inspired by a naturally occuring modification of mRNA cap - so