The Marchand group (UW, Seattle) unveiling cool new modalities for writing and reading XNAs. Enzymatic synthesis and nanopore sequencing of 12-letter supernumerary DNA disq.us/t/4jvygvq

In the future your hard drive will be full of squishy stuff. (Minor correction: the handle for Planetary Technologies is Planetary Technologies.)

Our paper (with @chikinlab and Alexander Sasse) benchmarking sequence-based DL models for personal gene expression prediction is out: nature.com/articles/s4158… A co-submission from Nilah Ioannidis' group, showing these results are consistent across data and models nature.com/articles/s4158…

Seems like a consensus is forming amongst many smart people! This is Jensen Huang, CEO of $NVDA Basically WATCH OUT for the impending biotech BOOM 💥

Thanks for the writeup Huanjia Zhang! And credit again to Keisuke Motone and Daphne Kontogiorgos-Heintz for leading the work.

Today in nature we compare several compositions of AI-based and classical methods of peptide binder design to make binders to nine different physiologically relevant hormones and cell signaling peptides: nature.com/articles/s4158… Work led with Susana Vazquez Torres and Preetham Venkatesh

Bending Unwinds DNA biorxiv.org/cgi/content/sh… #bioRxiv

thanks SEQanswers for this nice review of the SOTA in single-molecule protein sequencing tech

Powerful ‘nanopore’ DNA sequencing method tackles proteins too nature.com/articles/d4158…

Nanopore devices are tiny DNA sequencers, small enough to fit in a pocket. Once considered impossible to make, nanopores went from a "dream" sketched in a notebook to a physical device that has become ubiquitous. This is the story of how. press.asimov.com/articles/nanop…

🥳Latest work out from the lab describing a framework to proactively explore data hazards in #synbio research that is founded on emerging #ai and #datascience approaches. Collaborative effort across Jean Golding Institute + Bristol BioDesign Institute + international friends! 1/2 doi.org/10.1093/synbio…

Is DNA the future of digital data storage? Me for Chemistry World. Huge thanks go to Luis Ceze, Microsoft Research, Robert Grass, Emily Leproust, Thomas Heinis, Jeff Nivala, Mark Somoza and Olgica Milenkovic for sharing their wisdom with me chemistryworld.com/features/is-dn…

Excited to share a pre-print of our latest work, "The Genomic Computing Revolution: Defining the Next Decades of Accelerating Genomics"! 🧬💻 researchgate.net/publication/38…

I'm going on the record as a Protein World believer. Origins of life: The Protein Folding Problem all over again? | PNAS pnas.org/doi/10.1073/pn…

Have you ever wanted to directly synthesise kilo-base scale DNA fragments?✍️🧬Our latest pre-print does just that exploring the "doodling" capability of DNA polymerases to write DNA without a template😲Biology never fails to amaze! #synbio #nanopore #dna doi.org/10.1101/2024.0…

Not DNA Not RNA Not even epigenetic marks Inherited amyloid proteins nature.com/articles/s4155…

SMPS 2025 Registration is OPEN! It will take place in Bolzano (Italy), from January 20 to January 24, 2025, and there will be a two-day workshop for PhD and Postdoc. Please visit our website for details: smps2025.com/registration Early bird registration closes on October 15th, 2024

Retrons remixing phage vinyl on a loop