Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle dlvr.it/SXzzny

Really chuffed to be part of this work!

CODA is a method for 3D reconstruction of large tissues at subcellular resolution from serially sectioned H&E images, from Pei-Hsun Wu, Denis Wirtz and colleagues. @johnshopkins @ashleykiemen nature.com/articles/s4159…

SOOO EXCITED to finally, officially introduce CODA, a method for 3D reconstruction by myself,PeiHsun Wu Denis Wirtz, and Laura DeLong Wood

CODA can image large volumes of tissues/organs in humans, rodents, pre- and post-natal at single-cell resolution. By large volume, we mean multi cm^3. By single-cell, we mean type and (x, y, z) coordinates of individual cells in the 3D tissue. nature.com/articles/s4159…

CODA can detect new multicellular structures via deep-learning-guided imaging of large volume of tissues at cellular resolution. For example, we readily detect 3 types of pre-cancer lesions in pancreatic tissues: lobular, tubular, and dilated More here: nature.com/articles/s4159…

Structure = function is one of the first principles I learned in biology. Feels exhilarating to be part of exploring CODA’s potential to unearth new biological insights from 3D tissue structures

So unbelievably grateful to be part of this community! Thank you Laura DeLong Wood for your supportive mentorship and for being such an inspiring role model - I learn so much from you every day. Congratulations 🎉🎉🎉

It was a privilege to collaborate with you on this paper! Haoyang Wei valentina greco Tianchi Xin Thank you for the opportunity and many congratulations 🎉 🎉🎉

Really nice and inspiring reunion of Hopkins alumni and current fellows at Laura DeLong Wood's Lab with many great Friends and Scientists. Thank you for having us.

I’m beyond excited to share work from my PhD, co-led with Alicia Braxton, out today in Nature! We used CODA to map the anatomic and genomic properties of pancreatic cancer precursors. Led by the amazing Laura DeLong Wood and Denis Wirtz ! nature.com/articles/s4158…

It's out! We report 3D mapping of human pancreatic precancer and associated genetic alterations. With the brilliant Ashley Kiemen and Denis Wirtz . Tweetorial to follow soon. nature.com/articles/s4158…

Study led by Johns Hopkins Pathology in nature (rdcu.be/dGpnV): Extensive 3D analysis of human pancreas shows tiny precancers - PanINs - common in normal organs, multifocal & w/ heterogeneous gene mutations. Laura DeLong Wood Denis Wirtz Ashley Kiemen Alicia Braxton Hopkins GI Pathology

Immensely proud to have led the revisions on this amazing paper on 3D-mapping genetic heterogeneity in pancreatic precancers with CODA, out today nature ! Thank you for having me on the team Laura DeLong Wood Ashley Kiemen Denis Wirtz nature.com/articles/s4158…

The polyclonal PanINs were some of our prettiest too!

I’m very excited to share this preprint! Using CODA to co-register serial H&E with IHC images, we map CD45+ cells around PanINs to identify striking heterogeneity in 3D and distinct immune hotspots and cold spots

Incredibly excited and honoured to train at my dream residency Mass General Brigham Pathology! I’m utterly grateful to the many people who made my journey possible, especially my amazing PhD mentor & inspiration Laura DeLong Wood