Opioid-induced neurotoxicity has a spectrum of neuroradiologic manifestations. Are you familiar with these? @FrankGaillard at Radiopaedia.org Day 1 (supraclavicular radiology)

Thanks for amplifying our work! One clarification: opioid use and non-opioid analgesic use were each compared to non-analgesic use. Opioid use showed an increased risk of dementia, as noted, whereas non-opioid analgesic use did not.

Important study!

🙄44-year-old man with history of alcohol use disorder is found unresponsive. Toxicology positive for cocaine and fentanyl. 🏥🤔What syndrome explains the clinical context and radiologic pattern?

✅CHANTER syndrome (Cerebellar, Hippocampal, and Basal Nuclei Transient Edema with Restricted diffusion). 🐉Seen in acute intoxication, often with opioids or cocaine. 💡Cortical and white matter sparing helps distinguish it from anoxic injury. doi.org/10.1212/WNL.00…

Really nice educational video from Yale Department of Radiology & Biomedical Imaging on a case of opioid-associated amnestic syndrome - worth a view! 👀 Francis Deng, MD Andrew Kofke Joshua Madden, MD American Academy of Neurology m.youtube.com/watch?v=BK8uuq…

Losing teams can’t cash in with a bases-loaded hit for two innings in a row, then immediately respond by blowing the lead in sloppy fashion — the 2025 NY Yankees

Biggest win of the year for the @yankees That was either the peak or they’re onto something

Characteristic imaging patterns in toxic and acquired metabolic disorders of the central nervous system (schematic) 🧠🤮💊🫗

Studied food deserts in fellowship, interesting to see this study extending food insecurity to cognitive outcomes 🥗 ➡️ 🧠 JAMA Network Open jamanetwork.com/journals/jaman…

More evidence for opioid antagonism as a potential therapeutic intervention in Alzheimer’s spectrum disorders, this time at delta receptors Naltrexone is a non selective opioid antagonist w established track record and worth a pilot trial pubs.acs.org/doi/10.1021/ac…

Was honored to be at the naming of Mass DPH campus at Jamaica Plain after Dr Al DeMaria, a living legend in public health and huge influence on my own path

Great win New York Yankees!

🧠 Fentanyl misuse can cause CHANTER syndrome: Cerebellar, hippocampal and basal nuclei transient oedema with restricted diffusion. There’s a characteristic MRI pattern: restricted diffusion in the basal ganglia and hippocampi, with cerebellar oedema and haemorrhage. 📖 Open

Credit to Practical Neurology for raising awareness

Interesting story on complications associated with surviving opioid overdose — including mention of hippocampal injury — by Erika Fry in The Guardian theguardian.com/society/ng-int…

Would like to see a similar MCI trial for naltrexone, which has a clearer potential mechanism(s) including CNS penetrance, longer clinical experience, is more scalable based on cost