Celebrating recent publications and good health at Thee Parkside SF.

Congratulations to graduate student Joe Lobel for recent publication showing how intrinsically disordered regions of the scaffolding protein Pat1 contribute to mRNA decay! pnas.org/content/early/…

Check out our recent publication from the John Gross Lab and @memerman lab. @nchesarino and I teamed up on this project describing the SIVrcm Vif structure and adaptations that allowed this Vif to antagonize human A3G. sciencedirect.com/science/articl…

Check out preprint by graduate student Ryan Tibble showing how conformational control of mRNA decapping is coupled to the formation of biological condensates. Fantastic collaboration with @Jacek93345390 lab at Univ of Warsaw CeNT. biorxiv.org/content/10.110…

Phase-separated Edc3 Condensates amplify m7G-RNA Decapping! Dcp1/2 Enzymes partition into Edc3 Droplets & are catalytically activated. Using a Fluorescein-m7G Conjugate to study P-body Enzyme Kinetics. By Ryan Tibble & John Gross Lab. Now in: nature.com/articles/s4158…

Congratulations to lab member Leandrew Dailey who just passed his qualifying exam! Great day to celebrate with Detroit Pizza and cake from Hahdough.

SO to Jessie Peters for beautiful work on structure and mechanism of pox virus decapping enzyme D9 biorxiv.org/content/10.110… with fantastic cap analog chemistry from Jacek Jemielity.

Celebrating Dr. Ryan Tibble's thesis research today, prompting us to think deeply about how phase separation regulates enzyme activity.

Congratulations Jessie Peters , beautiful biochemical and structural studies of the Pox Virus mRNA decapping enzyme D9 with Jacek Jemielity! doi.org/10.1016/j.str.…

Thank you Sutapa Chakrabarti and Vincent Maciej for the Preview of Jessie Peters work that was published in Structure.

We are grateful for post-docs Xi Liu Xi Liu and Yen-Li Li as they tackle challenging problems in host-pathogen interactions and help train the next generation of scientists in our lab. #NPAW22 #ucsfNPAW #UCSFpostdocs

Pausing to thank everyone in the lab for a fantastic year.

Check out this review article by former graduate student Ryan Tibble dedicated to Gerhard Wagner for his 75th Birthday on the challenges and opportunities for NMR spectroscopy in biological condensates. authors.elsevier.com/sd/article/S10…

Congratulations to post-doc Yen-Li Li for her work on the structure of HIV-1 Vif in complex with human A3G. A fantastic collaboration with Caroline Langley , @nchesarino, @memerman of #FredHutch and Ignacia Echeverria, Caleigh Azumaya, Yifan Cheng of #UCSF. rdcu.be/c5bst

Interested in enzyme regulation in biological condensates? Want to live the California Dream? If yes, and yes, consider applying to our lab!

Congratulations to Victor Lam who defended his thesis on how 'SIV/HIV-1 Vif overcomes host defenses with one small trick'

End of summer, chocolate cake, and birthday celebrations.

UCSF Department of Pharmaceutical Chemistry is hiring faculty! Seeking candidates in #chemicalbiology, #computationalchemistry, #AI, #drugdiscovery and more. Apply now! aprecruit.ucsf.edu/JPF05273 #UCSF #QBI #FacultyJobs #academicjobs #UCSFPharmacy