🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Deucravacitinib (Sotyktu), a First-In-Class Oral, Allosteric Tyrosine Kinase 2 Inhibitor | drughunters.com/3gdrmDO In September 2022, the first de novo deuterated drug was approved by the FDA, deucravacitinib, a first-in-class oral, allosteric tyrosine kinase 2 (TYK2) inhibitor

Targeted protein phosphorylation, targeted protein restoration, and non-cysteine covalent inhibition among the strategies used by the 13 companies featured in this Premium Tech Review:

Thank You to Our Boston Event Sponsors | drughunters.com/3CZ5raS Thanks to this week’s Boston event sponsors for helping make another great Drug Hunter mixer possible! We’ll be in the SF Bay Area, San Diego, Research Triangle, and the UK + EU soon - sign up to get notified

Sept 2022 #MoleculesOfTheMonth | drughunters.com/MoTMsept22 No time to read before your next team meeting? Grab a coffee and check out these molecules. Get a free trial at drughunters.com/join-TW to get access to the full reviews, structure search, novel drug coverage, and more.

Stable Atropisomers in Drug Discovery via Catalysis | drughunters.com/3Wor1yy Examples of development candidates that are stable atropisomers, synthesis, and a kilo-scale synthesis of a Ph. III candidate using asymmetric catalysis in this article with the team at Sinocompound

How Does This Thing Get in the Brain?? | drughunter.com/how-does-this-… At AAPS 2022, I hosted a symposium where Ovoca Bio plc’s Head of Research told us about orenetide. Orenetide is an internationally approved drug for hypoactive sexual desire disorder (HSDD) (think Viagra for ♀️)...

The Landscape of AI/ML in Drug Discovery | drughunters.com/AIML1 The application of AI/ML methods to drug discovery has been an area of significant investment for at least 10 years now. This three-part Drug Hunter special on AI/ML in drug discovery summarizes the field.

Hope to see you there!

Saw a Forbes article recently claim that 23 clinical candidates were in development from AI/ML. What do these molecules look like and what do they target? The team's latest Premium report - try it here: drughunters.com/TW-trial

Small Molecule PI3K Inhibition in Oncology: What's Been Done and What's to Come? | drughunters.com/3TBF6Gi We reviewed the history and current status of PI3K inhibitors, including their approval history, resistance mechanisms, and the next generation of PI3K Inhibitors

Drug Discovery Strategies to Optimize Unbound Brain Concentrations in CNS Infectious Diseases, with Dennis Koester | lu.ma/w1q906iz December 8th, 1:00pm EST Presenting in silico, in vitro, and in vivo tools to assess, predict, and optimize brain-partitioning.

Insurrectionists like Gosar, Greene, and Boebart shouldn't serve in Congress. Members of Congress can object to them from being sworn into Congress on January 3 - and they should. It’s their constitutional duty. Sign this petition if you agree: sign.moveon.org/petitions/the-…

The Molecular Glue Degrader Landscape in 2022 | drughunters.com/3vhRHof Dive into molecular glue degraders and where this field might be headed in our latest review with the CAS team #drughunter

2022 Novel Small Molecule Drug Approvals There were 19 novel small molecule drugs approved by the FDA in 2022 - read more about their discovery, mechanisms of action, and differentiation and download the hi-res poster here: drughunters.com/3GxrXed #chemistry #medicine

🚨🚨🚨 Holy shit: A group of parents in Tennessee are OUTRAGED that a local school board caved to a conservative group and cancelled a librarian’s Mother's Day lesson inclusive to kids without moms. The parents boldly confronted the Hamilton County School Board and held nothing

BREAKING: Legendary actor Samuel L. Jackson brutally rips into Donald Trump in an explosive new interview with Rolling Stone. The brilliant tirade started with Jackson explaining that he was a "child of the Sixties" and he "grew up in segregation." Jackson says that some of the

"Firearms accounted for nearly 19% of childhood deaths (ages 1-18) in 2021" Interestingly, that's higher than the share of deaths due to childhood cancer yet ads raising money to prevent/Tx gunshots would likely be viewed as purely political... cnn.com/2023/08/08/us/…

If you’re covering Biden’s age issues without also acknowledging that Trump fell asleep and drooled on himself *every day* he was in court — or that he often didn’t start working until noon when he was in the White House — you aren’t being honest with the American people.

With fear for our Democracy, I dissent.