✅Considering the specificity of increased #Achilles #tendon #thickness for #LDL-C and Lp(a) accumulation, what would be the reference range for this increased thickness to be considered more sensitive and #earlier than a #blood #lipid #profile? ✅In the presence of #diabetes,

✅Considering #iPSC-PCs' ability to preserve the #pericyte-endothelial interface and their #hypoxia resistance, could we consider them a cutting-edge biological treatment for #PAD and difficult-to-manage #wounds in #diabetic #patients?🫰🐁🔬 ✅Considering iPSC-PCs' ability to

✅If #PRMT1 has a direct action on NF-κB b by #suppressing it under #physiological #conditions, how could we define the switch or #therapeutic #target in pathological conditions? Is it PRMT1 #overexpression or #suppression of NF-κB downstream signaling?🫰🫰🐁🐁 ✅Proinflammatory

✅What if we could target future therapies to combat #atherosclerosis toward #macrophage #LXR #receptors and thus control #cholesterol #efflux and #plaque development? ✅Speaking of precision and effective treatments, would silencing the #EEPD1 #endonuclease with #RNAi in

✅If blocking the #USP7-PDK1-AKT/NF-κB axis #inhibits #vascular #inflammatory response, increased permeability, and immune cell migration/adhesion in #pulmonary #vessels, would this option be truly effective in other vascular pathologies such as cerebral edema, #anaphylaxis,

✅If #TDSCs can differentiate and proliferate through the let-7b-5p/#CFTR #pathway, could we consider this the biological treatment of the future for #noninvasive #repair of damaged #menisci, #ligaments, and #cartilage? ✅If #CFTR #receptor agonists promote TDSC #proliferation,

✅If #hBVO cells retain their differentiation potential for more than 7 days, what impact would this #biological #treatment have on the resolution of #PAD and #diabetic #foot? ✅If #ETV2 is capable of inducing the fate of #ECs to #fibroblasts, how effective would its

✅If treatment with #DT-109 inhibits the progression of #fatty #liver #disease and lipid metabolism, could it be considered in the future as a drug that prevents the development of #atherosclerosis, without altering the diet? ✅Could DT-109 treatment be the end of #polypharmacy

✅Just like a #hydroelectric plant, which synthesizes and distributes electricity to homes, businesses, streetlights, neighborhoods, and cities, #mitochondria do the same for our #cells, #tissues, #organs, and #systems. However, water scarcity (stimulus) alters electricity

✅If #ODN prevents #cathepsin K from cleaving #ANGPT2 and its resulting elevated levels and #Tie2 #antagonism in inflammatory processes, could it be safely used in other non-acute pathologies that present with #hyperpermeability and #procoagulant #disorders? ✅Which action would

Wonderful paper!! Congratulation! 👏👏👏 ✅If we can inhibit non-muscle #myosin II (NMM-II) #ATPase with #blebbistatin and increase #transluminal #bridge formation by 76%, could we create a dual therapy with blebbistatin and #VEGF as an #innovative #treatment for #diabetic

✅Considering that this #vascular #Engineering #model is compatible with tissues subjected to distension, could it be a future therapeutic strategy for vascular pathologies of the #lung, #intestinal, #gastric, and #cardiac walls? ✅Could the vascular network constructed with

✅Considering the crucial role of #pericytes in preserving #vascular #integrity and function, as well as in #angiogenesis, would it be more innovative and proactive to target new #anticancer #therapies to pericytes and #VEGF, thereby preventing angiogenesis in the #tumor

✅Could the #ABCA1 #cassette #protein be the exact target that deserves all the attention when it comes to preventing foam cell formation and, consequently, #plaque development? ✅Proteins expressed in progressive plaque, such as #netrin-1, #semaphorin 3E, and #cadherins, be

✅Could implantation of #ADSC/#AAM/MC-derived #hydrogels be the definitive #biological #therapy in the future for patients with significant soft #tissue loss, such as #diabetic #ulcers, #burns, and #traumatic #wounds? ✅Given the #musculoskeletal #cellular #heterogeneity of

✅If #Notch3 expression by #pericytes is vital for stabilizing #endothelial #junctions, and #overexpressing #FGF2 prevents #aneurysm #dilation, would it be proactive to develop a dual Notch3/FGF2 therapy to #prevent wall dissection and subsequent aneurysm development? ✅If

✅Considering the #atheroprotective and anti-inflammatory capacity of #brown #adipocytes through the secretion of mediators such as IL-10, IL-4, and #TGFβ at the #perivascular #level, could we prevent the development of atherosclerosis in the future with brown adipose tissue

A recently published paper highlights the importance of exosomes and their ability to influence important biological processes, such as immune signaling, inflammation, tissue repair, and their potential to constitute excellent therapeutic strategies. 🫰🙏🐁🐁😊😊🔬🔬🧬🧬

Please feel cordially invited by CMPLPUCCHILE ISC RFP - LAC International Science Council to participate, both in person and online, in the interesting conference entitled "Present and Future Opportunities," led by the Executive Director of InterAmerican Network of Academies of Sciences (Inter-American Network of Academies of Sciences) and