An early view of a geometry of cysteine proteoforms, detailing how these oxiforms produce Oxi-Shapes. This is grounded in binomial theorem and Riemannian geometry. The shapes are produced by the Ricci curvature. github.com/JamesCobley/Pa…

Yes... cell.com/cell-systems/f…

Our News & Views on the recent advances in high-coverage single-cell proteomics (on Orbitrap Astral) nature.com/articles/s4159…

Who would have thought that cells would choose hydrogen cyanide, as a signaling molecule. Check our latest collaborative effort with Csaba Szabo’s lab (and others), published in Nature Metabolism: nature.com/articles/s4225…

Super fun ECU_Biology seminar today from James Cobley University of Dundee about abstract geometry in the space of possible protein oxiforms. Linked one of his papers below for reference to the concept. #Redox #Biochemistry #PirateNation journals.physiology.org/doi/abs/10.115…

There's a common misconception that biological systems are irreducable genetic systems that coordinate metabolism to do their bidding. The only way to arrive at that model is to ignore the underlying chemistry and physics. #Bioenergetics #Biochemistry evolution-outreach.biomedcentral.com/articles/10.10…

Eur J Appl Physiol now welcomes reviews from all thinkers—whether or not they identify as physiologists. A great review is not about labels but about curiosity, depth & synthesis. Young scientists, your fresh takes are especially invited. My editorial: link.springer.com/article/10.100…

Timescales in Cell Biology

James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal. onlinelibrary.wiley.com/doi/10.1111/mm…

A sharp, thought-provoking critique of the Bayesian brain hypothesis. Bold ideas, fearless writing. Essential for anyone in neuropsychology, motor control, biomechanics or concerned with falsifiability and biological plausibility. link.springer.com/article/10.100…

🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼 biorxiv.org/content/10.110…

Assessing FDR in proteomics using full proteome recombinant libraries: pubs.acs.org/doi/full/10.10…. A very elegant work and a benchmarking dataset useful for many other things too. Protein FDR higher than precursor FDR likely due to paralogues - and this needs to be researched

Preprint on information and chaos in redox proteomics preprints.org/manuscript/202…

Time and time again, it's always the same picture. DIA-NN controls FDR correctly as data reliability has been the main goal at DIA-NN's conception back in 2017 and a priority since then. Data from a very nice paper introducing the Thin-diaPASEF concept: doi.org/10.1093/dnares….

Is the erythrocyte a simple cell that just passively carries oxygen during exercise? NO. In our new study in Sports Medicine with Angelo D'Alessandro we show that erythrocyte energy and redox metabolism affects muscle oxygenation and exercise performance. link.springer.com/article/10.100…

A prevailing idea in exercise physiology seems to be that the only erythrocyte factor affecting performance is hematocrit and hemoglobin levels. Is it really that simple? 1/3

Was a great pleasure to contribute to this work pubs.acs.org/doi/10.1021/ja…. DIA-NN release with support soon.

If you believe that the current framework of redox biology (oxidative stress/redox signalling) is vague, then the approach introduced in this paper offers a geometric/physical basis for how redox modifications (cysteine oxidation) happen, interact, and shape biological outcomes.

Is “oxidative stress” a useful concept in biology? In this work, led by Nikos, we argue that the term “oxidative stress” is devoid of biological meaning and, even worse, misleading.