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A 70-year-old man with a history of hypertension and chronic migraine presented with 10 months of progressive generalized muscle weakness and stiffness. Take the Clinical Challenge. ja.ma/3Srpib4

Most viewed this week from JAMA Oncology: Viewpoint discusses how "skimming the median" can exaggerate survival gains in clinical trials, underscoring the need to critically evaluate Kaplan-Meier curves alongside hazard ratios. ja.ma/45zBluy

Revised reference intervals for serum free light chains reduced false-positive rates for LC-MGUS diagnosis by 82%. ja.ma/4dy3NPo

JAMA Oncology is now on Bluesky! 🦋 Follow us there for the latest original research, opinions, and reviews that advance the science of oncology and improve the clinical care of patients with cancer. ➡️ ja.ma/43WqKIP

Some of the best parts of #ASCO25 is the opportunity to meet in person your research collaborators from around the world!! Check one of our groups’ most recent publications on “National Cancer System Characteristics and Global Pan-Cancer Outcomes: jamanetwork.com/journals/jamao…

📢 Calling all #ASCO25 attendees! Stay up to date with everything JAMA Oncology—follow us on Bluesky. ➡️ ja.ma/3ZIUrKY

Interval breast cancer (IntCa) rates remain high despite mammographic screening, highlighting the need for personalized screening based on risk factors like high breast density, hormone replacement therapy, and family history. ja.ma/4jHqZfO

A cell-free DNA blood test could be an option for patients who repeatedly decline colonoscopy or stool testing for #ColorectalCancer screening. #ASCO25 Read the new JAMA Original Investigation to learn more. ja.ma/3FC1wWU

A study of 1.6 million US cancer patients in 2023 found 47.3% had a smoking history, with 14.7% currently smoking at diagnosis. ja.ma/43ErxwM

For select breast cancer patients with complete response to neoadjuvant systemic therapy, radiotherapy alone without breast surgery may be feasible, as no tumor recurrences were observed at 5-year follow-up. ja.ma/4jxfdEA

Survivors of childhood cancer undergo considerable accelerated aging in terms of early onset and excess risk of chronic health conditions. ja.ma/4kV9dqo

In childhood cancer survivors, obesity was linked to a higher risk of various subsequent neoplasm types, while increased physical activity was associated with a reduced risk. ja.ma/4dLqDTQ

Most viewed this week from JAMA Oncology: While phase 3 oncology trials frequently report success based on alternative endpoints, actual enhancements in overall survival and quality of life are uncommon. ja.ma/4jyRiED

Approximately one-third of patients treated on TT 2 protocol and half of those treated on TT 3A protocol were alive at 15 to 20 years post-diagnosis. ja.ma/43uAn1m

From JAMA Internal Medicine: Mailed self-collection was effective for increasing #CervicalCancer screening participation among never- and under-screened women in a safety net health setting. ja.ma/442jwTH

Viewpoint: As palliative care clinicians, we urge the adoption of buprenorphine as a first-line opioid for cancer pain due to its effectiveness and safety profile. ja.ma/45bAgsQ

Most viewed this week from JAMA Oncology: While phase 3 oncology trials frequently report success based on alternative endpoints, actual enhancements in overall survival and quality of life are uncommon. ja.ma/4dVJAU8

Initiating fecal immunochemical test screening for colorectal cancer at ages 40 to 49 leads to reductions in colorectal cancer mortality and incidence. ja.ma/45mHxGm

Cancer rates among people with HIV have declined for certain types, like non-Hodgkin lymphoma and Kaposi sarcoma, due to improved HIV care, though the risk for other cancers remains largely unchanged. ja.ma/4nhUmZ9

"Caring for fasting oncology patients during Ramadan requires a thoughtful, individualized approach." This Viewpoint discusses how oncology clinicians can provide culturally sensitive care for Muslim cancer patients fasting during Ramadan. ja.ma/3HGG7fP