We love the excitement & results from the community on AlphaFold 3 and are doubling the AF Server daily job limit to 20. Happy to also share that we're working on releasing the AF3 model (incl weights) for academic use, which doesn’t depend on our research infra, within 6 months.

We have a tenure track opening for a computational scientist with exciting ideas for #machinelearning in molecular biology at the MRC Laboratory of Molecular Biology, incl generous core funding from Medical Research Council & an unparalleled scientific environment. RTs appreciated! 🤗 jobs.sciencecareers.org/job/657824/res…

Research Highlight by Arunima Singh: ModelAngelo is a deep learning-based approach that automates the process of model building for protein and RNA- or DNA-containing complexes, as well as identification of unknown proteins, from cryoEM maps. nature.com/articles/s4159…

Wes Robertson is starting his own research group in the LMB’s PNAC Division, where he will develop genome engineering tools for the de novo synthesis of non-model gut bacteria, with the ultimate aim of reprogramming the microbiome. Read more: www2.mrc-lmb.cam.ac.uk/wes-robertson-… #LMBNews

I'm happy to share our latest foray into the world of cryo-EM. It's been fun collaborating with the ChimeraX and Phenix teams! Feedback on experiences with it much appreciated! Likelihood-based interactive local docking into cryo-EM maps in ChimeraX biorxiv.org/content/10.110…

Great opportunity for anyone in mathematical data science to have a real impact in a highly dynamic and exciting field of molecular biology!

Proudly introduced Dr Zala Sekne who passed her viva with flying colors and no corrections. First PhDone from our lab! It has been an incredible ride.

Check out our new preprint! Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry – a perspective. biorxiv.org/content/10.110…

Check out this preprint, very interesting work!

I feel for Joe, this was obviously not an easy process. He far exceeded my expectations as president and stepping aside now will help preserve that legacy 🫡

DynaMight from Sjors Scheres MRC Laboratory of Molecular Biology models continuous structural heterogeneity in cryo-EM datasets, leading to an improved reconstruction of the consensus structure. The study also explores the issue of overfitting when modeling structural flexibility. nature.com/articles/s4159…

The RELION 5 tomo paper is out in FEBS Open Bio !

Happy to share my first postdoc paper, out today in Nature! nature.com/articles/s4158… This started with a simple question: Can we learn more about viral proteins by looking at their predicted structures? /1

Super cool work!

Kiarash Jamali I was impressed by how well ModelAngelo performed on the unknown capsid. One can envision, a few years hence, a fully end-to-end software (wrapping concepts like SmartScope, Relion, and ModelAngelo) where you put a grid in and get a diagnostic result out.

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

We’re thrilled to announce Diana Arseni is starting her own research group in our Neurobiology Division! Diana will lead research into the lysosomal protein TMEM106B to elucidate its role in ageing and disease. Read more: www2.mrc-lmb.cam.ac.uk/diana-arseni-a… #LMBNews

Considering a PhD in molecular biology? Make sure to check out the projects on offer at the LMB! www2.mrc-lmb.cam.ac.uk/students/inter… General applications by 3rd DEC. US Gates Scholarship applications by 16th OCT. LMB PhD Programme #PhD