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A man in his 60s presented to the hospital with fever, joint pain, and second-degree atrioventricular block. Physical examination revealed diffuse xanthomata, most prominent in the periorbital region. What is your diagnosis? ja.ma/3H7u2QB

Editor in Chief Kanade Shinkai highlights JAMA Dermatology's achievements in 2024. ja.ma/45fJ15e

This case report describes a woman in her 60s with smoking history, chronic productive cough, weight loss, and asymptomatic thickening of the palmar skin. ja.ma/3YUUX8x

Chronic cutaneous immune-related adverse events (cirAEs) from immune checkpoint inhibitors (ICIs) can persist for years, with pruritus, morbilliform eruptions, and bullous pemphigoid-like eruptions being the most common and severe. ja.ma/4kFVZ0P

Mohs surgery was associated with improved outcomes in the treatment of primary high-stage cutaneous squamous cell carcinoma compared with wide local excision. ja.ma/4kQbNOR

Most viewed this week from JAMA Dermatology: A man in his 50s presented with a 5-year history of progressive blue-gray discoloration of sun-exposed areas, including the nose, cheeks, ears, and hands. ja.ma/3ZiOXXi

In this retrospective cohort study, there was no increased risk of major cardiovascular events in patients with nicotinamide exposure. ja.ma/45djcmc

The AI-driven AIRIS prognostication system outperformed existing stratification systems in predicting poor outcomes for cutaneous squamous cell carcinoma. ja.ma/441olwz

This Editorial discusses a novel risk stratification system for cutaneous squamous cell carcinoma that was developed using a retrieval augmented generation–enabled large language model. ja.ma/3FGnaJC

Pediatric patients with hidradenitis suppurativa have a higher prevalence of comorbidities, including obesity, acne vulgaris, anxiety, and hirsutism. ja.ma/4kLxWNv

Patients with lupus and a history of cutaneous lupus erythematosus had higher interferon-stimulated gene expression in both nonlesional skin and peripheral blood mononuclear cells. ja.ma/3T6MrzF

This case report describes a woman in her 60s with hypertrophy of dorsal tongue papillae in a honeycomb pattern along with papillomatous growth of the gingiva. ja.ma/3SD4XQ7

Pediatric vitiligo is associated with increased risks of sensorineural and mixed hearing loss, but not with ocular conditions. ja.ma/3ZE70aH

Systematic review and meta-analysis: The Memorial Sloan Kettering Cancer Center and Melanoma Institute of Australia models are the most validated and effective risk prediction models for sentinel lymph node biopsy positivity in melanoma. ja.ma/442GF7g

In this nonrandomized pilot trial, selumetinib resulted in some decrease in cutaneous neurofibromas volume. ja.ma/4lf9IMa

Dupilumab treatment in atopic dermatitis patients is associated with a 58% higher risk of developing psoriasis compared to other systemic agents. ja.ma/4jTNRbO

This Consensus Statement from National Psoriasis Foundation defines on-treatment remission for plaque psoriasis as maintaining 0% body surface involvement or an Investigator Global Assessment score of 0 for at least six months during therapy. ja.ma/3ZykPav

In this JAMA Dermatology Author Interviews podcast, listen to author April Armstrong discuss defining on-treatment remission in plaque psoriasis with host Adewole Adamson. ja.ma/4ecG4ou

This study describes the clinical and laboratory features, management, and long-term outcomes of drug reaction with eosinophilia and systemic symptoms (DRESS) in a cohort of children. ja.ma/4n9vlyS

A man in his 60s with a medical history of hypertension, hyperlipidemia, and coronary artery disease presented with multiple asymptomatic purpuric macules that had been persistent for more than 2 decades. What is your diagnosis? ja.ma/4kLUAFZ