Do you ever question prior decisions as you gain new information? Do you wonder if immune cells do too? Check out our KuehLab preprint about a flexible T cell decision-making strategy that enables robust and scalable control of immunological memory tinyurl.com/58mha28t (1/n)

Out today in nature, we describe HHV-6 reactivation in T cells, including therapeutic CAR T cells. I’m so grateful to have worked with an all-star team during my time in the Ansu Satpathy lab that led to these findings. nature.com/articles/s4158… 1/n

MetaGate: Interactive Analysis of High-Dimensional Cytometry Data with Meta Data Integration dlvr.it/SyqZF7

1/ My work on epigenetic memory with Leonid Mirny, Dino Osmanovic is out Science Magazine! science.org/doi/10.1126/sc… How can *stable* memory be encoded in patterns of *dynamic* epigenetic marks? We find 3D folding of genome can stabilize memory, if 3 ingredients are present...

Did you ever wonder why our marrow is located inside of our *bones*, #MedTwitter? There’s no a priori anatomical reason it should be sited there. Blood cells could form in our spleens & livers, as they do during our fetal lives; or elsewhere, as in some animals. Let’s discuss! /1

And Spatial VDJ is out! More to follow, but for now, joy and gratitude for the privilege to work with the wonderful Kim Thrane Qirong Lin @Jeff_Mold Jonas Frisén Joakim Lundeberg and many more collaborators. Karolinska Institutet SciLifeLab KTH Royal Institute of Technology science.org/doi/10.1126/sc…

Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣️ ki.varbi.com/what:job/jobID…

Wow. Very cool findings.

Exciting news! Our new paper in Cell Host & Microbe shows that memory T cells efficiently cross-recognize the new SARS-CoV-2 variant BA.2.86, which has more than 30 additional spike mutations. #SARSCoV2 #COVID19 #BA286 #Tcells sciencedirect.com/science/articl…

The Engblom lab is hiring a postdoc and a research assistant ! Come join us to understand B cell clonal dynamics in cancer and beyond. See specific details below and how to apply: Postdoc: ki.varbi.com/en/what:job/jo… Research assistant: ki.varbi.com/en/what:job/jo…

Finally!

Excited that paper is published today! Go read "Clonally heritable gene expression imparts a layer of diversity within cell types" at Cell Systems, authors.elsevier.com/sd/article/S24…. Thank you to @Jeff_Mold for including me on this project with so many fantastic scientists.

How do neonates with primitive immune system survive in the world? We found: (1/5) Science Immunology (in Rudd & Grimson labs; with Neva & Connor, fellow Tweeters Oyebola Oyesola Cybelle Tabilas Kristel Yee Mon @eliataitwojno) #SingleCell #multiomics #neonatalImmunity scim.ag/5Z2

What a PERFFect day to share our new preprint! With Tsion Abay #BobStickels Meril Takizawa @ChaligneRonan and Ansu Satpathy, we introduce PERFF-seq, a new experimental approach to studying rare cells with scRNA-seq via transcript-specific enrichment. biorxiv.org/content/10.110… 1/n

Very excited (& nervous) to share what we've been working on the past many years. Only took 3 first authors (Schreuder the experimentalist, Dr Dawn Lin the analyst, and @syzmath the modeller) & co-senior Weber (computational, modeller, SynBio extraordinaire) biorxiv.org/content/10.110…

Grades of DNA methylation as the basis of epigenetic cell memory... must-read. biorxiv.org/content/10.110…

Congratulations Vivien - really interesting findings!

Several amazing PhD positions in Data Driven Life Sciences within national SciLifeLab DDLS program. See the details here: scilifelab.se/data-driven/dd…

Happy to share our new NK cell resource in Nature Immunology: "Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping." nature.com/articles/s4159…. Herman K. Netskar, @AlinePfefferle, Horowitz Lab @Icahn School of Medicine Mount Sinai Human Cell Atlas, Precision Immunotherapy Alliance, UiO - Det medisinske fakultet

Happy to share the final work from my post-doc with MalmbergLab published in Cell Stem Cell today cell.com/cell-stem-cell… extensive 15-post-🧵 below