The fungus Alternaria alternata can elicit IgE-mediated respiratory diseases. How do its spores and hyphae contribute to allergen content, and how might this knowledge impact methods for allergen extract quality control? Read an Editors’ Choice report. bit.ly/3WVWaun

New data suggest that asthma patients on biologic therapies have lowered postvaccination SARS-CoV-2 immunity, which could place them at increased risk of COVID-19 infection. Here’s the Editors’ Choice report. bit.ly/3YMI5C3

New data establish the structural basis of two human IgE mAb nonoverlapping epitopes on the dust mite allergen Der p 2. The epitopes may provide molecular targets for the future design of allergy therapeutics. Learn more. bit.ly/4dN3lf8

Aspirin-exacerbated respiratory disease (AERD) involves dysregulated type 2 inflammation. New findings suggest that AERD patients also have an overpopulation of oncostatin M, IL-6, and non-type 2 hematopoietic cytokines that also may contribute to disease. bit.ly/3Aww6hN

One way that the skin protects against environmental threats is through a lipid-rich substance called sebum. Does the immune system contribute to its production? New data suggest a role for IL-4 and IL-13. The issue also includes editorial commentary. bit.ly/3AtBP86

Hereditary angioedema (HAE) is a genetic disorder that manifests as recurrent angioedema attacks. An Editors’ Choice report suggests a pivotal role for Inter-a-trypsin inhibitor heavy chain 4. Learn about the implications for disease pathogenesis. bit.ly/3XbTcTZ

Introducing the September cover. This month's theme is Dendritic Cells. The Editor's Choice Summaries are available at: authors.elsevier.com/a/1jitTKs2xHy01

Most innate lymphoid cells are found in tissues, but they have also been described within the circulation. Their ready accessibility in peripheral and cord blood makes them attractive candidates for novel therapeutic applications. Here’s a review. bit.ly/3XxKFL1

New data from a Brief Report demonstrate that pretreating human basophils with anti-IgE-CD33L significantly suppresses basophil degranulation. The findings could have implications for food, drug, and environmental allergies. Read on. bit.ly/4cy54nD

A Brief Report’s findings associate asthma with a notable increase in the 2-year incidence and the prevalence of AD in a nationally representative US sample. Read on. bit.ly/4fU72kU

Neutrophilic asthma (NA) is associated with steroid resistance and IL-1b overproduction; however, the exact underlying mechanism remains unclear. New findings suggest an association with otulin deficiency. Here’s the Editors’ Choice paper. bit.ly/3MFQPT6

Blood and sputum eosinophil counts are imperfect measures of eosinophilic airway inflammation. Could eosinophil peroxidase be a valid protein biomarker? Review new data. The issue also includes editorial commentary on the findings. bit.ly/3zgMzGG

New data suggest a key role for ALOX15+ M2 macrophages in epithelial remodeling in chronic rhinosinusitis with nasal polyps. Targeting the interaction between ALOX15+ M2 macrophages and epithelial cells could be a potential mitigation strategy. bit.ly/3zgMMcW

Data suggest that children with severe recurrent wheeze often have a silent syndrome of lung rhinovirus infection with granulocytic bronchoalveolitis and elevated markers of systemic inflammation. Read the Editors’ Choice paper. bit.ly/3zeVt7s

The diagnosis of polyethylene glycol (PEG) allergy is complicated by poor performance of current skin testing protocols. A Brief Report’s data suggest that using PEGylated liposomes as compared to PEG-containing medications may improve results. Read on. bit.ly/4ctG40B

Lactotransferrin (LFT) is an iron-binding protein with antimicrobial and anti-inflammatory functions. New data suggest it may be an anti-T2 biomarker, and its expression levels may allow the determination of eosinophilic and neutrophilic asthma. bit.ly/3MCERK9

Basal cells are a heterogenous population, and specific changes in their behavior are associated with chronic barrier dysfunction. What role might they play in epithelial barrier defects under conditions of allergic rhinitis? Here’s more. bit.ly/4dUwtBF

Sirtuin (Sirt) proteins have been implicated in chronic rhinosinusitis. New findings suggest that SIRT5 promotes disease development by supporting alternative polarization of macrophages, and it may offer a potential target for interventions. bit.ly/3Zm8rLy

An Editors’ Choice paper identifies 2 distinct gene signatures associated with clinical features in patients with chronic rhinosinusitis with nasal polyps. The endotype signatures were associated with magnitude of dupilumab response. bit.ly/3ZjMtZh

Palmoplantar pustulosis largely affects smokers and manifests with painful pustular eruptions on the hands and soles. Read new data that implicate deregulated TH2 responses and cigarette smoking in disease pathogenesis. bit.ly/3TkweaP