Now in Science Immunology: @crow_lab & Casanova Lab #review the #human monogenic disorders underlying insufficient & excessive type I #interferon signaling. These disorders may inform prevention & treatment of #viral & #inflammatory #diseases! #IFN #PID bit.ly/SciImm_adm8185

A novel disease-causing gene of herpes simplex encephalitis ( #HSE ): #TMEFF1, which inhibits the neurological entry of HSV-1 via interacting NECTIN-1 (a key HSV-1 receptor). Thrilled to have contributed to this amazing work!

Excited to see the work published nature. Excellent summary in thread below. Big collaborative effort with Shen-Ying Zhang, Casanova Lab + many more. Special thanks to Yi-Hao Chan Lab, Zhiyong Liu, Paul Bastard and in my lab Noopur Khobrekar, Param Amin, Gabriele Ciceri & @harschnitz

Nature research paper: Human TMEFF1 is a restriction factor for herpes simplex virus in the brain go.nature.com/3ShfVL9

Thank you, Noopur! We're are grateful for the incredible collaboration with Lorenz and the Casanova Lab Shen-Ying Zhang teams. Excited for our ongoing and future projects!

I've written a small blog post on this incredible discovery of a surprising new mechanism through which neurons in the brain resist viral infection. This is in a way reminiscent of the discovery of loss of CCR5 protecting against HIV infection, which led to the development of

Thanks Yunfei An for the invitation. The discussions were incredibly enriching, and it was wonderful to meet old friends and make new ones. Chongqing’s hospitality, especially the hotpot 🍲, was unforgettable! Looking forward to future collaborations and more shared experiences.

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

1/ We are excited to share our report in #JEM that about 10% of severe tick-borne encephalitis (TBE) cases, triggered by the TBE virus (TBEV), are due to pre-existing auto-Abs neutralizing type I IFNs (doi.org/10.1084/jem.20…).

The latest comprehensive review of HSE is out—an absolute must-read! Packed with insights and detail, it’s worth savoring word by word. Congratulations to Shen-Ying Zhang Casanova Lab on this incredible work!

I am thrilled to become the Editor of this new journal and grateful to both RUP and IAPIDS for their trust ! I also thank Megan Cooper who graciously accepted to become the Deputy Editor !

The 2025 Novo Nordisk Prize goes to Professor Jean-Laurent Casanova for his pioneering genetic discoveries! For decades, scientists believed that infections were determined solely by viruses and bacteria. But Professor Jean-Laurent Casanova’s groundbreaking research has revealed

Journal of Human Immunity (JHI) Journal of Human Immunity is here! Read the inaugural editorial by Casanova Lab outlining #JHI’s vision as the destination for groundbreaking research in human immunity and inborn errors of immunity. hubs.la/Q038p-Gl0 #OpenAccess

What an amazing experience riding freely in NYC with the lab! I used to love biking, but gave it up after moving to the city. Grateful for the opportunity to be part of it—huge thanks to Casanova Lab for organizing and rekindling that joy!