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My lab at The University of Chicago has an open postdoc position. AT #ASHG2023 AND interested in Statistical genetics and functional genomics? Please reach out and let's chat!

We are excited to share Genotype-Neighborhood Associations, GeNA, a new tool adapting our CNA framework to detect cell states associated in abundance with genetic variants at genome-wide scale in high-dimensional single-cell data w/ Soumya Raychaudhuri সৌম্য রায়চৌধুরী doi.org/10.1101/2023.1… 🧵

Excited to share our review paper in Cell! With Sasha Gusev Sohini Ramachandran Yang I Li we discuss the genetic and molecular architecture of human traits, future opportunities and challenges and ways forward. authors.elsevier.com/a/1igrbL7PXqPfU

Very interesting and impressive work! Congrats to my friend Wenhe!

Our work led by Lili Wang on identifying trans genetic effects of gene networks is out in Cell Genomics today!

CRISPR editing is hard. Editing in primary human cells is even harder. Editing non-coding variants in human cells is downright impossible. I am happy to share our work aimed at addressing this problem with Soumya Raychaudhuri সৌম্য রায়চৌধুরী Broad Institute Mass General Brigham biorxiv.org/content/10.110…

check out our review discussing immune diversity through the lens of evolutionary biology! we argue that past selection underlies variation in disease risk across populations and offer new avenues to pursue that couple empirical and genomics approaches shorturl.at/ghMO9

Our work on trans regulation of proteome and how protein-protein interactions play a role in it🧬.

Our work is out in AJHG! I wholeheartedly thank all the co-authors marie.saitou Andy Dahl Qingbo Seiha Wang for their time and effort! All four of us started our own labs between 2019 and 2021 and the pandemic didn't make things easy. Super proud of everyone.

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen

📣Excited to share my last postdoc paper with Soumya Raychaudhuri সৌম্য রায়চৌধুরী on eQTL mechanisms depending on where the RNA is in the cell! Brigham and Women’s Research Broad Institute TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇