Phase 2 trial shows drug to lower brain pressure could treat blinding IIH headaches Paper at bit.ly/3mxD4vW UniBirmingham News @IMSR_UoB @unibirm_MDS IIH UK @IIHDrBirmingham #IIH

🧪Results from a new trial have found that a diabetes drug could be used to treat a form of blinding headache called IIH. Research from @IMSR_UoB researchers found the drug led to lower pressure and fewer headaches. Our story: birmingham.ac.uk/news/2023/new-…

Thanks to research by @IIHDrBirmingham and the team from Uni of Birmingham and University Hospitals Birmingham working with Invex Therapeutics, a new drug could be available for the many thousands who live with IIH, and the findings are described as "exciting progress" by Shelly Williams from IIH UK.

🧠 Easing the pressure | Birmingham clinical trial finds that an injectable peptide usually used to treat type 2 diabetes can be effective in reducing disabling headaches in patients with Idiopathic Intercranial Hypertension (#IIH) > birminghamhealthpartners.co.uk/new-drug-can-l… @IIHDrBirmingham

Patients with ‘blinding’ headaches known as Idiopathic Intercranial Hypertension could be treated with an injectable peptide used for type 2 diabetes, a new trial published in Brain led by @IIHDrBirmingham from @IMSR_UoB has found. birmingham.ac.uk/news/2023/new-…

New drug to lower brain pressure could treat blinding IIH headaches. Phase two trial saw significant reduction in pressure in the brain & monthly headaches: birmingham.ac.uk/news/2023/new-… published in Brain academic.oup.com/brain/article-… @IIHDrBirmingham, Dr Susan Mollan, James L. Mitchell, IIH UK

Brain 👉academic.oup.com/brain/advance-… International Headache Society European Headache Federation Neurology Trainees UKNOSoc Dr Susan Mollan

Interesting - James L. Mitchell @IIHDrBirmingham & colleagues report the results of a randomized clinical trial exploring the effect of GLP-1R agonist exenatide on idiopathic intracranial hypertension; Significantly lowered intracranial pressure; On to Phase 3 academic.oup.com/brain/advance-…

“The effect of GLP-1RA exenatide on idiopathic intracranial hypertension: a randomized clinical trial” by Alex Sinclair et al. Brain academic.oup.com/brain/advance-…

Patients Needed for Phase 3 IIH Trial - article in miVision now recruiting US, Australia, New Zealand, Uk clinicaltrials.gov/ct2/show/NCT05… invextherapeutics.com ⁦Invex Therapeutics⁩ ⁦mivision⁩ ⁦Dr Clare Fraser⁩ ⁦Australian and New Zealand Headache Society⁩ mivision.com.au/2023/03/patien…

New clinical trial: Promise for a type 2 diabetes drug to treat idiopathic intracranial hypertension (IIH), which can cause chronic #headache & permanent vision loss. @IIHDrBirmingham James L. Mitchell Dr Susan Mollan UniBirmingham News @EyeUHBTrust University Hospitals Birmingham Brain: bit.ly/3JNwE4Z

Today we mark 28 years since the #Srebrenica genocide in which 8372 Bosniak civilians were brutally murdered. They were killed after Serb forces attacked the UN "safe area" of Srebrenica in July 1995. #SrebrenicaGenocide ▪️

CURLY Trial BWC Research Dept Birmingham Clinical Trials Unit

Alimajstorovic et al. report novel changes in lipid metabolites and meal-stimulated glucagon-like peptide-1 levels following bariatric surgery in idiopathic intracranial hypertension, which were associated with changes in intracranial pressure. tinyurl.com/5cffm45a

Our new publication in @BrainComms highlights novel perturbations in lipid metabolism and GLP-1 secretion are mechanistically important in driving a reduction in #ICP following weight loss in patients with #IIH Translational Brain Science Research Birmingham UK Warwick Dunn academic.oup.com/braincomms/art…

👉important work to read #IIH of course, made in Birmingham

The race is on! Our first 5 sites are open for the CURLY Trial. Best of luck to everyone. Curly.digitrial.com

Huge congratulations to Shrouk Messahel and the team at Alder Hey ED for the first recruit in CURLY Trial Mixed emotions about them beating the Brum ED team😆 curly.digitrial.com

** The Curly Trial is now open ** And I believe it has the best animated patient information EVER Setting high standards for children's research CURLY Trial curly.digitrial.com

2 further PERUKI Emergency Departments have recruited their first patients to the CURLY trial. Massive congratulations to Shammi Ramlakhan and the Sheffield Children's team for yesterday’s recruit. And extra special hugs to my own team at BWC NHS Trust for today’s success! CURLY Trial