Thrilled that our work on generative AI for dynamic protein-ligand binding is now on the cover of nature Zhuoran Qiao / 乔卓然 Weili Nie Thomas Miller nature.com/articles/s4225…

Glad to share our work on profiling metalloproteomes by thermal proteome profiling and many potential metalloprotein candidates discovered rdcu.be/dzDGq

Thrilled to share our collaboration work with Peng and Xinyuan Fan on Nature Chemistry. With a new bioorthogonal reaction, the chimeric translation system, and a new computer algorithm, we can cage and decage Trp on virtually any protein in living cells. nature.com/articles/s4155…

Some required reading from Derek on the Chinese CRO situation science.org/content/blog-p…

While I hate TikTok as a parent, this ban strikes me as an egregious removal of free speech rights and scary concentration of authoritative coercive power into gov't hands... banning websites/apps... All done under the guise of national security... Be wary, very wary...

The 7 major ways China has changed between 2019 and 2024

After slight delay due to market downturn, RA Capital is proud to unveil its long planned suite of biotech ETFs to democratize biotech investing. We can make cures as long as policy doesn’t undermine. We need insurance reform, not price controls. prnewswire.com/news-releases/…

Excited to share my postdoctoral work in the Cravatt lab. We described a set of stereo- and regiochemically defined spirocycle acrylamides and their chemical proteomic analysis in human cancer cells, leading to the discovery of ERCC3 degraders and other novel ligands.

“The papers leading to my 2016 Lasker prize were published more than 10y ago. Most would be considered quaint, preliminary and barely publishable today. One would today be criticized for failing to include a mechanism and animal experiments” nature⁩ nature.com/articles/54538…

Congrats, Evert!

Biggest lesson I learned about platforms is that they really become valuable when you have a killer app… the right indication best suited to the tech. Jnana is a great example of a platform with a killer app.

BioRender finally made some changes to their license conditions and now claim their product is compatible with Open Access. Sorry to say that these conditions are legally invalid and don't fix anything. 1/

We were impressed by the great quality of our abstract challenge and are excited to have talks by the winners at the Virtual Virtual ChemBioTalks (inactive account) on September 24th: Yuanjin Zhang | 张沅珒, Ben Cravatt lab Jana Volaric, Ed Tate @ZM_cheng, Marc Vendrell lab Joel Rüegger, @mariovdstelt lab

Thanks for organizing such a great event. Highly recommend!

The GLP-1 drugs are the most important drug class breakthrough in medical history. We're still learning how they have such broad impact, especially about their anti-inflammatory effects, systemically and in the brain nature.com/articles/d4158… A new feature nature, by Mariana Lenharo

Check out our News&Views highlighting the work of Keriann Backus in Nature Chemical Biology : a new form of cellular stress and collateral degradation of proteins induced by electrophilic small molecule fragments. Work of Caroline Stanton + Kayla Nutsch, PhD rdcu.be/dXZpw

This is 🤯. Awesome to see.

Excited to share that the AlphaFold 3 model code and weights are now available for academic use. Looking forward to seeing what new research this unlocks and how the research community builds on AlphaFold 3 for scientific discoveries github.com/google-deepmin… 1/2