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As today is World Cancer Day, it seems like the perfect time to put together a thread of some of the most groundbreaking cancer research from The University of Sheffield. Take a look at some of our highlights in the thread below! 👇#WorldCancerDay

Introducing Dr Matt Winter, YCR NHS Fellow. Their research interests include breast cancer and gestational trophoblastic disease. See more here: bit.ly/3gqA91X

Introducing Dr Satya Garikipati, YCR NHS Academy Fellow. Their research interests include head and neck cancers, and the impacts of smoking.

🗣️Calling all clinical researchers – Cancer Research UK Policy is running a survey to hear about your experience working in #ClinicalResearch, including the barriers & challenges that need addressing by Government. Complete the survey by 9 August 👇 bit.ly/44n0NjD

The Yorkshire Cancer Research (YCR) CONNECTS fellowship scheme wants to change that Yorkshire is one of the regions hardest hit by cancer. #cancerresearch Sheffield Cancer Research Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺

Yorkshire Cancer Research (YCR) CONNECTS fellowship has 4 strategic areas: Early diagnosis and access to treatment; Improving clinical outcomes in common malignancies; Lung cancer; and Improved health and wellbeing with and beyond cancer Sheffield Cancer Research Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺

How best to decide which new cancer treatments get funded? Nick's fellowship aims to benefit patients by improving the use of patient data from clinical trials so that we can make better decisions on which cancer treatments to prioritise. Nick Latimer Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺 Sheffield Cancer Research

Lung cancer is Yorkshire’s most common cancer. Many patients are excluded from treatment or at risk of lung damage because of poor respiratory function. Bilal’s fellowship aims to change this through developing innovative scanning methods for functional image-guided therapy.

Catriona’s fellowship has focused on improving the integration of palliative care within cancer care, providing support throughout the illness,  including during bereavement, and exploring ways to recognise and reduce inequities #hapc #PalliativeCare #hpm Catriona Mayland

Andy’s research has focused on the use of bone anabolic agents in myeloma bone disease. Using an anti Dkk1 antibody and by targeting the TGF-beta pathway, he has demonstrated substantial protection against osteolytic bone disease in myeloma. (1/2) Andrew Chantry Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺

Andy has also developed novel strategies to target myeloma tumour including the development of a myeloma specific oncolytic adeno-viral construct. (2/2) Andrew Chantry Sheffield Uni - Clinical Medicine 🦠 💉 🫀💙🔬🩺 Sheffield Cancer Research

Immunotherapy has brought huge survival benefits to the treatment of melanoma. It is increasingly used but little is known about the long-term effects, which can be life-changing. Jo’s research is focussed on these ‘Late effects’ and the experience and support needs of patients.

Sarah’s research focussed on the role and response of primary care in COVID-19 end-of-life care,  improving identification of palliative care needs, the integration of palliative care services in the community to reduce inequalities, and paediatric palliative care #palliativecare

Sarah was a YCR CONNECTS fellow from 2020-2022, additionally being awarded a Churchill Fellowship (2020) to research new ways to improve palliative care in the primary health sector. She was appointed Associate Professor of Palliative Care at the University of Leeds in 2022.

Satya’s research is focussed on the use of PETMRI scans in radiotherapy planning of head and neck cancer patients. An early phase study checks the feasibility of obtaining PETMRI scans with immobilisation and to assess the impact of additional imaging on the accuracy of planning.

Matt’s fellowship has focused on evaluating the potential role of immunotherapy in the low-risk treatment of gestational trophoblastic neoplasia and further developing a valuable international database.

Robin's fellowship focussed on developing the early phase trials portfolio, especially in lung cancer. He is now a very research active NHS Consultant, with interests in lung cancer, sarcoma, germ cell tumours, Teenage and Young Adults (TYA) and early phase clinical trials.

1/2 Juha’s fellowship focussed on ex vivo drug screening technology for functional diagnostic assessment of patient-specific efficacy of targeted cancer therapies.

2/2 The developed methods include AI image analysis drug screening, a novel organoid microarray and HTS reverse-phase-protein-arrays for modelling immunotherapy efficacy.