Valid points by Vince here

Good thread by Vince. Read up and down. I want to add a few thoughts. 1/N

Preprint on "BWT construction and search at the terabase scale". We can compress 100 human genomes to 11GB in 21 hours, find SMEMs with it, do affine-gap alignment and retrieve similar local haplotypes. 7.3Tb commonly sequenced bacterial genomes ⇒ 30GB arxiv.org/abs/2409.00613

Start of three days off to visit my partner and future in-laws in MKE! It’s been a while since I’ve been on a 777.

TIL method of moments began with a mixture model of crab measurements.

New preprint out on biorxiv! I propose a model for the stability of sex chromosome systems based only on the operation of stabilizing selection on polygenic traits. This will be a short thread on the main results 1/ biorxiv.org/content/10.110…

I like this chart so much more than culture war framings — it’s completely rational for drivers to prefer a bigger-than -average car which does in fact make you safer. The problem is that this race makes the roads less safe on average over time.