Congratulations!! Kousuke's talk at IMGC2023 was based on his paper on genetic variants of regulatory elements in autoimmune disease. Read Kousuke's BACH2 paper here: nature.com/articles/s4158…

#Postdoc job of the week: Join the Ryan Tewhey Tewhey Lab to use novel, high-throughput techniques to study genetic mechanisms underlying complex traits, & the impact genetic variation has on gene regulatory function: …cksonlaboratory.wd1.myworkdayjobs.com/en-US/External… #postdocs #postdocjobs #sciencetwitter

Getting emotional about friendship and an ice bucket on a Thursday. 🥲🧊

New in Science Magazine, JAX's Ryan Tewhey Tewhey Lab & colleagues I.D. 800 human-specific conserved deletions (hCONDELS) that confer significant differences in regulatory activity, highlighting several with putative effects on brain development: jax.org/news-and-insig…

New in Science Magazine, JAX's Ryan Tewhey Tewhey Lab & colleagues I.D. 800 human-specific conserved deletions (hCONDELS) that confer significant differences in regulatory activity, highlighting several with putative effects on brain development: jax.org/news-and-insig…

It’s official, the Twitter bio has been changed - ya girl’s a PhD candidate! 🥳 Grateful for all the support from my friends, family and committee! Super relieved to be done and even more ready for some of that Maine summer!! ☀️(Note: loading bar is not to scale…at all…)

I’m excited to share some work I co-lead with Rodrigo I Castro and spanned the labs of Pardis Sabeti, Steve Reilly, and Ryan Tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. biorxiv.org/content/10.110… 1/n

SO happy this is live! See Sager Gosai tweet explaining our amazing collab with Rodrigo I Castro, Ryan Tewhey, Pardis Sabeti! TLDR: Used AI to learn to 'read' the genome's regulatory code and 'write' new, synthetic functions. Evolution didn't create this neuronal enhancer, but it works!

Thank you!!! Honored to be a Tufts GSBS Rosenberg Fellow 🥳 Grateful for the nomination from my program and the endless support from my PI and lab ☺️ Ryan Tewhey Tewhey Lab

This is by far the most convincing regulatory DNA synthetic design paper to date. Congrats to the authors 1/

#Postdoc job of the week: Join the Ryan Tewhey Tewhey Lab to use novel, high-throughput techniques to study genetic mechanisms underlying complex traits, & the impact genetic variation has on gene regulatory function: …cksonlaboratory.wd1.myworkdayjobs.com/en-US/External… #postdocs #postdocjobs

Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.110… See below for a 🧵. 1/n

2024 JAX Scholar Takeshi Iwasaki discusses his work in the Tewhey Lab identifying #genomicvariants and genetic mechanisms that influence #autoimmunedisease, and the importance of linking genetic variants to disease presentation or risk: bit.ly/3XGRDhi

Yes Takeshi!!!! JAX Scholar and Tewhey Lab post doc Takeshi Iwasaki talks about his work in the lab ⬇️🧬

Happy National Postdoc Appreciation Week to Tewhey Lab post-doc Takeshi Iwasaki!! 🥳🎉 Takeshi is studying regulatory variants in autoimmune disease and is actually this year’s The Jackson Laboratory JAX scholar!!🏆🧬 #NPAW2024

Using #AI, a Broad/The Jackson Laboratory /Yale School of Medicine team has developed a way to decipher the language of genetic switches that turn genes on and off, and designed new, synthetic switches that control genes' expression in specific cell types. broad.io/CRE-AI Steve Reilly

Excited to share our sequence design work published in nature. I had the privilege of co-leading this effort alongside my friend and colleague Sager Gosai under the supervision of Ryan Tewhey, Steve Reilly, and Pardis Sabeti nature.com/articles/s4158… 1/7

I’m thrilled to share that our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” was published online in nature. nature.com/articles/s4158… #genomics #MachineLearning #SyntheticBiology #bioengineering 1/9

@MaineCalling's Patty Wight spoke with JAX researcher Ryan Tewhey (Tewhey Lab) regarding his recent publication in nature. 📻 Listen to the coverage: mainepublic.org/health/2024-10… 💡 The study, published with the @BroadInstitute of MIT and Harvard, and Yale University University, showcases