The PROTACtable genome | Nature Reviews Drug Discovery nature.com/articles/s4157…

The Spiegel laboratory (David A Spiegel) reports bifunctional molecules that recruit proteins to the asialoglycoprotein receptor and target them for lysosomal turnover. Free to read: rdcu.be/cviPo nature.com/articles/s4158…

Welcome the newest class of T32 trainees!

Our new PROTAC synthesis platform is online. authors.elsevier.com/a/1eshaoqiQAjm…

Our modeling work on PROTAC-Mediated Ternary Complexes pubs.acs.org/doi/10.1021/ac…

2022 Common Fund Glycoscience Program dinner!!

A review paper on PROTAC delivery with my colleague.

Antibody targeting of E3 ubiquitin ligases for receptor degradation Genentech nature.com/articles/s4158…

Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins go.nature.com/3R6V2ix

BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron nature.com/articles/s4158…

Lauren Rault, an undergraduate chemistry student working in the lab of Professor Weiping Tang, has earned an Undergraduate Award in Organic Chemistry from the American Chemical Society! Rault is being recognized for her coursework and research accomplishments in the Tang Lab, School of Pharmacy, UW-Madison Lab.

We're proud of Christopher Stevens, School of Pharmacy PhD student in Pharmaceutical Sciences—selected for a UW-Madison Graduate School Graduate Student Service Scholarship for exceptional service contributions to the university outside of his research with Weiping Tang. bit.ly/3LMtteM

A Modular Chemistry Platform for the Development of a Cereblon E3 Ligase-Based Partial PROTAC Library (W. Tang et al.) Weiping Tang onlinelibrary.wiley.com/doi/10.1002/cb…

Development of Potent and Selective Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Degraders | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

Targeted degradation of extracellular secreted and membrane proteins - ScienceDirect sciencedirect.com/science/articl…

The November special issue of Trends in Pharmacological Sciences features advances in TPD strategies and opportunities Many thanks to the authors Weiping Tang Danette Daniels Behnam Nabet Fred Hutchinson Cancer Center Breanna Zerfas Lyn Jones Fass Lab Weizmann Institute Gopal Sapkota RCNS MedChem Research Group Matosevic Lab

A new preprint led by Yunrui Qiu! Using IGME non-Markovian models, we identified non-canonical PPIs between KRAS and VHL for PROTAC design. A top-ranked PPI aligns well with a co-crystal structure from an experimentally designed PROTAC with potent efficacy! go.shr.lc/3yUU6dz

Thanks to the Research Forward scheme for funding our development of a chemical feature-based Transformer platform to predict molecular glues! Excited to collaborate with Sharon Y. Li and Weiping Tang. Our 1st grant in targeted protein degradation! research.wisc.edu/a-novel-deep-l…

For readers interested in approaches for extracellular targeted protein degradation, here's a comprehensive review bit.ly/489BXVZ rdcu.be/dLaX8