I am excited to share the latest genetic findings from the Exeter @HIgenes team; non-coding mutations affecting the regulation of the pancreatic beta-cell disallowed gene HK1, are a common cause of #congenitalhyperinsulinism disq.us/t/43edsx1 CHI Exeter Med School (1/3)

Amazing 🙌🏼 congratulations @ladybakerkent

Genetic discoveries like this derepress my hidden desire to become a clinical geneticist :) A beautiful revelation of a set of non-coding mutations that allow a disallowed gene to express in beta cells leading to congenital hyperinsulinism. x.com/flanagan_se/st…

🍋 They say when life gives you lemons, make lemonade 🍋 DUKE AL released his poetry book ‘Bittersweet’ yesterday, to celebrate the centenary and shine a light on living with type 1 - the highs and lows, the hypers & the hypos. Buy your copy today! orlo.uk/DXIQ1

The 'silent pandemic' is not silent anymore. New data, published in today’s #Lancet, show the true global cost of #AMR. We must use these data as a warning signal to spur on action at every level. #AMRSOS 👉 bit.ly/3nBEvas

Great visit to the blood sciences team Royal Devon NHS RDE site today. Loved watching the robotic sorting of tests. Innovative team, continuously growing and developing to support our patients in hospital, the community, primary care as well as further afield, thanks to all

Great to see the @HIgenes team showcasing their fantastic research at the SGGD meeting in Lille. It’s not always about diabetes 🧬 @HIgenes ExeterDiabetes

The latest CLARITY IBD paper "Vaccine escape, increased breakthrough and reinfection in IFX-treated patients with IBD during the Omicron wave of the #COVID19 pandemic" is online via bit.ly/3zC441w Nick Kennedy, @nchanchlani1, Simeng Lin, James Goodhand, Tariq Ahmad

Great to see the hard work of Nick Thomas & our fab #StartRight team at #EASD2022 #DiabetesDiagnosis @ExterMed Royal Devon NHS Diabetes UK #EFSD National Institute for Health and Care Research AnitaHill Robert Bolt Beverley Shields PeteTippett Tim McDonald Angus Jones @athattersley ColinDayan #ExeterDiabetes

Sian Grace presenting at #EASD2022 #antibody data from #StartRight participants has enabled researchers to stratify the risk of early insulin requirement in diabetes patients NIHR Exeter Clinical Research Facility Exeter Med School Royal Devon NHS Angus Jones Tim McDonald @rderesearch University of Bristol University of Dundee

Many congratulations to Dr. Dr. Alice Hughes @aliceehughes on completing your PhD today!! 🥳🍾🥂⭐️

A team at the University of Exeter have discovered the cause of the rare condition Congenital Hyperinsulinism in a part of a genome that has been underresearched. Read: bit.ly/3DCXSar bit.ly/3UmviBn Orli Bahcall @ExeterDiabetes #ExeterDiabetes

After years of searching, we have finally found it – a new, common genetic cause of #congenitalhyperinsulinism Until now these disease-causing variants have remained frustrating elusive, they had been hiding deep in the non-coding genome University of Exeter Faculty of Health & Life Sci University of Exeter ExeterDiabetes

De novo mutations in a silencer causing hypoglycemia! I don’t think we understand what transcriptional silencers are, but this is certainly one. Defects caused ectopic transcription and abnormal glucose sensing Congrats Sarah Flanagan & team for this breakthrough in human genetics

Congratulations Sian Grace for successfully defending your thesis today! Exeter Med School Angus Jones Kathleen Gillespie Anna Long time to celebrate an excellent thesis. Thanks to examiners Noel G Morgan Parth Narendran

Fantastic that the great work of Exeter Clinical Laboratory Blood Sciences recognised for their work #UKMedLab23 Royal Devon NHS rachel nice Mandy Perry

Please join us in congratulating our final awardee for the 10th annual Sugar Soirée, Sarah Flanagan! Sarah’s work focuses on finding the genetic causes of HI; she has made outstanding contributions to this line of research through her 2022 groundbreaking publication in the ...

867 people living with congenital hyperinsulinism have benefitted from genetic testing as a result of this partnership. The reach of this project is huge - 61 countries and counting! Exeter Med School #ExeterDiabetes #openhyperinsulinismgenesproject

Landmark study led by @DrElisaDeFranco & Nick Owens shows ZNF808 loss causes human pancreatic agenesis. This is the 1st congenital disease caused by loss of a primate-specific gene and highlights that conservation isn't always a useful marker of disease causality Veera Rajagopal 