A potentially useful table for anyone interested in understanding the recommended usage of some of the newer antibacterials, e.g. latest beta-lactam/inhibitor combinations. #AMR #AMS

"If bacteria were sentient,they likely would not care which route antibiotics took on their way to eradicating them. Rather, they would care about how much antibiotic made it to their place of residence & whether it metabolically poisoned them" #idxposts academic.oup.com/cid/advance-ar…

🔥BALANCE RCT🔥 74 hospitals in 7 countries 3,608 patients A 7-day course of antibiotics for hospitalized patients with bloodstream infections was non inferior to 14d within a 4% prespecified margin for mortality at 90 days Brad Spellberg Todd C. Lee nejm.org/doi/full/10.10…

Endocarditis therapy has long been based on opinions of eminent experts rather than high-quality evidence Wow Brad Spellberg Our editorial 🔥PUBLISHED 🔥 with the b🌟st Todd C. Lee Emily McDonald Endocarditis Therapy: The Move From Expert Opinion to Evidence sciencedirect.com/science/articl…

Conventional intermittent dosing remains the current standard of care for beta-lactam antibiotics 🆕🔥 Editorial with Jason Roberts Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings? #idxposts onlinelibrary.wiley.com/doi/10.1111/im…

A brief tweetorial. The belief that IV is more effective than oral Abx is incorrect. No data to support it. Contrary data to refute it. And it makes no logical sense. The bugs can't know how the abx got there. They only know if enough gets there to inhibit their growth...

🔥🔥 NEW 🔥🔥 Year In Review: Top Infectious Diseases Articles From 2024 Our new post, a great collaboration with my friend 🌟 Bug Pharmacist 💊🧫 Tim Gauthier 1️⃣6️⃣⚡️🆔 RCTs JAMA The Lancet ✨ 7️⃣Syst Reviews/Meta 3️⃣🌏Guidelines WikiGuidelines ✨️ #idxposts idstewardship.com/year-review-to…

Flu season is here! 🌡️ A quick thread on understanding the basics (and dangers) of influenza (flu)

Excellent review on antibiotic duration for various common bacterial infections - again proving that in most cases, #shorterisbetter

2024 was a 🔥 year in ID 🆕💫 Clinical Infectious Diseases @VUMC_ID Jeff Freiberg, MD, PhD What’s Hot This Year in ID Clinical Science The review highlights some of the most important trials and clinical trends in infectious diseases over the past year #idxposts academic.oup.com/cid/article/do…

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis ➡️Standard of care since the 1990s and is currently recommended by several major GI societies ➡️Weak supporting evidence ➡️No clear mortality benefit doi.org/10.1093/cid/ci…

HIV+ & brain lesion? 🧠 Toxo – #1 cause, multiple ring-enhancing lesions 🦠 TB – Tuberculoma, may mimic tumors 🍄 Crypto – Often with meningitis 🧬 PML – JC virus, non-enhancing white matter lesions 🐛 Neurocysticercosis – Cysts, endemic areas 🧫 Abscess (Nocardia, etc.)

Night shifts are associated with a higher risk of death ☠️👇 Here are some evidence based approaches to maintaining healthy while working shifts. A 🧵 (1/x)

🆕 Hypertension Classification New AHA 2024 guidelines have omitted ❌Hypertensive urgency ❌Hypertensive crisis

Why shorter is better "It's the same efficacy, but safer and with less selection for resistance." "If you're going to give antibiotics to people who don't need them, at least do us the courtesy of doing it for a brief period of time." Brad Spellberg cidrap.umn.edu/antimicrobial-…

The most anticipated RCT in ID 🔥SNAP RCT🔥The largest RCT 2 date in SA bactermia N:1341 Cefazolin Vs ASPs ((flu)cloxacillin) for MSSA bacteremia Cefazolin is non-inferior (90d mortality)& less AKI than ASPs A practice-changer RCT that must change the guidelines #ESCMIDGlobal

Hi PHOO, I just sent you a detailed email response. Thank you for asking this very important question, which affords me the opportunity to offer one of my trademark antibiotic rants. Oooh, feels good, haven't done one of these in a while! Ok...strap in, here we go...

Timeline of chikungunya fever Typical viral load, symptoms, involved immune cells, and antibody titres during different phases of disease are depicted doi.org/10.1080/215055…

🆕🔥Prospective,multinational PK study by 🌟 Jason Roberts Meropenem & pip/tazo optimised dosing regimens for critically ill patients receiving RRT Dosing nomograms developed to inform dosing for different RRT settings, urine outputs & target conc link.springer.com/article/10.100…

🔥Just published The GAME CHANGER RCT Among patients with a hospital-acquired or health-care-associated Gram-negative bloodstream infection, cefiderocol resulted in non-inferior but not superior 14-day mortality compared with standard of care #IDXposts share.google/wnXjZuhBYFBOA3…