Make fecal DNA great again!

John von Neumann provides an excellent sense of perspective for anyone that thinks a little too highly of their own intellect.

#genomics2020 Gill Bejerano, computational tool building! Nothing experimental or medical genomics makes sense except in light of computational tools. This should be front and center. This is about thinking about logistic supply lines. Won't get far or fight well without them.

For my PhD, I am working on a website that helps researchers query a bunch of databases based on a gene and mutation of interest (for human or for 🐭🐟🐛🦟...) If you have 3 minutes, I would love some feedback on how to improve ease-of-use! marrvel.org Thank you!!

COMPare We sent correction letters on every misreported clinical trial in the world's biggest medical journals, to see how the editors - and the trialists - would react. What happened next? trialsjournal.biomedcentral.com/articles/10.11… trialsjournal.biomedcentral.com/articles/10.11… ...

Poster sessions amirite?

And if you wanted to see how the sausage got made ... here's a movie of the paper-writing process!

ChIP-seq of plasma cell-free nucleosomes identifies cell-of-origin gene expression programs disq.us/t/3eptczy

Recorded live from #ASCO19: Kim Chi, MD, author of the TITAN trial, explains the results of this double-blind, phase 3 trial that tested the use of apalutamide for metastatic, castration-sensitive #prostatecancer. View all NEJM papers released at ASCO: NEJM.org/asco

I’ve admired David Goodsell’s brilliant structure visualization work for years, and now you can create a Goodsell-like image from any PDB file, at his web site! ccsb.scripps.edu/illustrate/. Just made this one of the histone octamer, 1AOI.

Our latest, led by Elie Ritch @cherberts1 & Simon Fu, dissecting mismatch repair defective metastatic PCa via plasma cfDNA targeted and whole exome sequencing – published in Clinical Cancer Research: bit.ly/35kaC30 1/6

Researchers in Alex Wyatt's (Alex Wyatt) lab at the Vancouver Prostate Centre have shown that mismatch repair-defective metastatic #ProstateCancer can be identified and characterized using plasma circulating tumour DNA. Elie Ritch @cherberts1 bit.ly/2YegXdJ

Social isolation isn't gonna stop the Wyatt lab team from supporting #PlaidforDad 😷 Vancouver Prostate Centre Alex Wyatt

👉 Need help understanding DevOps? Let David Hasselhoff FLAVOR FLAV @Carole_Baskin help simplify @AWScloud @Kubernetesio Docker for you. #CelebritiesExplainDevOps Backstory: cto.ai/blog/celebriti…

Serious productivity boost for reading code on GitHub. 1️⃣. Go to any repo you are interested in on GitHub. 2️⃣. Replace "github" with "github1s" (one + s) in the browser address bar. 3️⃣. Enjoy browsing code like you would in VS Code. This is huge 🔥

Too many papers focus on the promise of liquid biopsy without recognizing the limitations. Here’s @cherberts1 and my take on how ctDNA fraction (tumor purity) and assay design combine to constrain what types of genomic alteration can be detected in ctDNA. authors.elsevier.com/a/1dKt28Z12yMG…

Happy to share our study on the indolent genomics of lung recurrent HSPC! bit.ly/3N7AapK. Kim Van der Eecken meCurt Herberts Alex Wyatt Piet Ost This is a rare underexplored subtype of PCa, with some evidence supporting a distinct clinical trajectory from liver mets.🧵👇1/7

Hot off the preprint presses: Our study of tumor evolution in DLBCL! Key question: why do patients with late relapses seem to do better on salvage therapy than patients with primary refractory or early relapse disease? 1/8 medrxiv.org/content/10.110… #lymsm #lymphoma

Here’s a paper from our team in npj Journals Precision Oncology, led by newly-minted PhD Dr. Elie Ritch (Elie Ritch), using machine learning to classify prostate cancer ctDNA samples by DNA damage repair phenotype on the basis of mutational signatures. rdcu.be/c7tvo