Three next-gen computational tools (AlphaMissense, ESM1b, VARITY) now calibrated for clinical variant classification! They can reach Strong evidence for pathogenicity & Moderate for benignity, performing similarly to previous tools Vikas Pejaver bit.ly/44t30N7

The five states that are perhaps the deepest blue politically & have the highest taxes are losing people at the fastest pace. 5 states with the largest exodus percentage: 1) New Jersey 2) Illinois 3) New York 4) California 5) Massachusetts Surprise: WV w/ most inbound migration

Using >130 human & 12 primate haplotypes, we reconstruct the chromosome 22q11.2 evolution to identify haplotype structures linked to deletions or inversions, explaining the lower prevalence of 22q11.2 deletion syndrome in individuals of African descent. biorxiv.org/content/10.110…

A bit concerning to contemplate: Could an innovation be so effective at releasing us from an evolutionary pressure that it catastrophically impairs an essential natural capacity?

The challenges of #precisionmedicine. Study reveals ~50% of the genetic variants reported in diverse adult genetic practices are of uncertain clinical significance. bit.ly/46wJZdI #VUS #genomicmedicine

Wow... The FDA just posted an archive of Complete Response Letters from 2020-2024 open.fda.gov/apis/other/app…

Wait.. BIG caveat. These CRL letters are for drugs that were later approved. The really good stuff -- CRLs for drugs not/never approved are not being disclosed.

Context: CCR5-∆32, known for the HIV resistance it confers on homozygotes, has a hotly debated evolutionary history. It's the variant that He Jiankui tried to introduce in the first editing of the human germline with CRISPR/Cas.

Breaking the Billion: Blockbuster Trajectories For Drug Revenues Below is the timeline for revenue-milestone-spread for various blockbuster Oncology drugs. Source: Wells Fargo