Full manuscript at IJROBP now - late toxicity is a concern for hypofractionation in postprostatectomy setting. redjournal.org/article/S0360-…

🔥 Final analysis: CheckMate 577 Adjuvant nivolumab in resected stage II/III EC/GEJC post-CRT & surgery ✅ DFS benefit maintained 21.8 vs 10.8 mo HR 0.76 (95% CI 0.63–0.91) 🧠 DMFS improved 27.3 vs 14.6 mo HR 0.75 (95% CI 0.62–0.90) ⚠️ OS not statistically significant 51.7 vs

Again brings up issue of control arm of esopec not having this option Prajnan Das, MD, MS, MPH Dr. Nina Niu Sanford Krishan Jethwa

#ASCO25: In COG ACNS1123, children with NGGCT treated with proton vs. photon WVRT had significantly better long-term IQ outcomes. First prospective data showing protons preserve cognition in pediatric brain RT. Photon RT linked to IQ decline over time. 🔗 meetings.asco.org/abstracts-pres…

🚨 Placebo Controlled Randomized Trial: Memantine given w/Brain RT Improved Cognitive Outcomes & QOL 🚨🚨🚨

Congrats Dr. Surendran & Colleagues Benefit memantine seen in both the SRS cohort and the HA-WBRT cohort Mayo Clinic Radiation Oncology Nadia Laack, MD MS you will be interested in this one meetings.asco.org/abstracts-pres…

X-torial: Cleaning up the misinformation about Joe Biden and #ProstateCancer that I am reading everywhere. The purpose of this is to provide education from someone who treats and studies PCa for a living, lead the USA National Comprehensive Cancer Network (NCCN) PCa guidelines, hold leadership in NRG Oncology National Cancer Institute

Navigational bronchoscopy as the new standard for biopsy of lung nodules? Non-inferiority trial NEJM compared robotic bronch to transthoracic needle biopsy with similar accuracy (79% vs 74%) but bronch with lower risk of pneumothorax (3.3% vs 28.3%). nejm.org/doi/full/10.10…

#LCSM @asco PROVE ME WRONG! Early vs Late Time-of-Day (3PM cutoff) ICI dosing in 1st-line stage IIIC-IV NSCLC: randomized trial shows near doubling of PFS (13.2 vs 6.5 mo), better OS & ORR with morning infusions. Circadian rhythm matters? Will practice change? This is the

Chemoradiotherapy and Local Excision vs Total Mesorectal Excision in T2-T3ab, N0, M0 Rectal Cancer: The TAUTEM Randomized Clinical Trial ⁦JAMA Surgery⁩ jamanetwork.com/journals/jamas…

PEACE-3 trial is out! Addition of Radium-223 to enza prolonged rPFS by 3 months in 1L mCRPC. Final OS pending annalsofoncology.org/article/S0923-….

This study reports on incredible results with adjuvant cemiplimab in high-risk cutaneous squamous cell carcinoma. nejm.org/doi/full/10.10…

📢 #ASCO25: In pts w/ 5–20 brain mets, SRS/SRT led to fewer symptoms & less functional interference vs HA-WBRT, w/ similar OS (~8.4 mo). 🔬 Phase 3 RCT (n=196) 💡 SRS/SRT = new SoC for brain mets >4? meetings.asco.org/abstracts-pres… #RadOnc #NeuroOnc #SRS #WBRT #BrainMets

Structured exercise program improves overall survival in colon cancer. Full text here: nejm.org/doi/full/10.10…

🚨MATTERHORN🚨 🔎948 pts Stage II-IVa G/GEJ Adenocarcinoma Ph3 RCT: Peri-op FLOT +/- Durva Durva associated with: ✅⬆️EFS2 67% vs. 59%, p<0.001 ✅⬆️pCR 19% vs. 7% BUT 🚫🔺OS2 76% vs. 70%, p=NS Full pub here in NEJM : nejm.org/doi/full/10.10… #ASCO2025

Evaluation of brachytherapy applicators and their association with mor... sciencedirect.com/science/articl… Does this data make you move to just using T+R? Sushil Matthew Harkenrider, MD Junzo Chino Lara Hathout Andrew Farach, MD Brandon Dyer Scott Glaser

Randomized Trial 8 Gy vs. SBRT 20Gy Bone Met · “Negative trial” but CR rates tended to favor SBRT · No increase pain flare w/SBRT ascopubs.org/doi/10.1200/JC…

🔥NSABP- B51 is out! Practice changing trial supporting RT de-escalation in cN1, ypN0 breast cancer 👉longer follow up desired 👉applicability across subtypes? 👉Impact of more modern systemic therapies ? NRG Oncology ASTRO #BreastCancer nejm.org/doi/full/10.10…

I learned this week that SABR-COMET patient #1 recently passed away, more than 12 years after enrollment, with no recurrence since his original SABR. We initially treated him for a left adrenal met. It’s an interesting story… ⬇️⬇️⬇️

Reirradiation dose constraints in clinical practice: Results of an international survey. sciencedirect.com/science/articl…