Ok this paper is bonkers and I love it biorxiv.org/content/10.110…

Evo: a foundation model for genomics! Using a well suited architecture, Evo learns from billions of bp of genomic sequence and performs well on several zero-shot prediction tasks on RNA, DNA and protein. Beautiful paper from Brian Hie & Patrick Hsu at Arc Institute

Capping a 10-year-long adventure, in today's Cell we unveil the molecular mechanism whereby the fertilized egg permanently blocks polyspermy, a lethal condition for the embryo: doi.org/10.1016/j.cell… #structuralbiology #reproduction #fertilization #infertility

New open access paper out in NatureEcoEvo TLDR: - Humans pass on more viruses to other vertebrates than they do to us - Generalist viruses (with broad host range) require fewer mutations to infect a novel host 1/ nature.com/articles/s4155…

nature.com/articles/s4155… Have a look at the article I reposted by Prof Francois Balloux, Cedric C.S. Tan and Lucy van Dorp if you're interested in viruses and their evolutionary signature when jump hosts. I had the pleasure of writing a news and views piece about this work with Christophe Dessimoz

Amazing! the choanoflagellate Choanoeca flexa blurs the lines between clonal and aggregative multicellularity, adapting to extreme salinity with a unique life cycle! A leap forward in understanding animal origins and multicellular evolution. 🌊🔬 Thrilled also by this week's

🧬🔬 Nice dive into how #metagenomics & single-cell genomics are revolutionizing our understanding of the tree of life by @eme_laura & Daniel Tamarit 🧬 #MicrobialDiversity #genomics #singlecell #biodiversity #protists

A nitrogen-fixing organelle, or “nitroplast,” has been identified in a marine alga. This discovery sheds light on the evolutionary transition from endosymbiont to organelle. Learn more from a recent issue of Science: scim.ag/6KY

Companies like Deepmind do not have any requirements to make their research available. I signed the letter below because they chose to publish their work and different standards were applied to the Alphafold 3 publication as those applied to others.

Super excited to introduce ESM3, a 1.4B, 7B, and 98B(!) series of multimodal generative models for proteins. It's been an incredible journey working on this for the past 7 months at EvolutionaryScale. Check out the blog post and paper!

7/ In particular, we showcase gLM2's ability to directly learn coevolutionary signal in protein-protein interfaces with no supervision! The learned contact maps can be extracted using Zhidian Zhang et al's categorial Jacobian method.

Here’s our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trained a new version of RF2 to screen millions of protein pairs, and identify > 18k binary interactions. biorxiv.org/content/10.110…

Free scientific illustrations for biologists! 😍 NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

Many congratulations Benjamin Podbilewicz, new EMBO member 2024!

This is a foundational achievement. MMseqs2-GPU virtually *erases* the bottleneck of homology search in many workflows, including structure prediction. Christian Dallago @milot_mirdita @thesteinegger, Felix, Bertil, and Alejandro too! developer.nvidia.com/blog/boost-alp…

Today OpenAI announced o3, its next-gen reasoning model. We've worked with OpenAI to test it on ARC-AGI, and we believe it represents a significant breakthrough in getting AI to adapt to novel tasks. It scores 75.7% on the semi-private eval in low-compute mode (for $20 per task

FastOMA is out now in Nature Methods 🎉: nature.com/articles/s4159… A new orthology inference algorithm that scales linearly and is highly accurate. FastOMA can process all >2000 eukaryotic UniProt ref proteomes <24 hours 🚀. Try it out at github.com/DessimozLab/fa…

Have you checked out our behind-the-paper blog post on FastOMA? Read it here go.nature.com/4a3V9q3 I’ll give you a quick intro to orthology, a bit of history of orthology methods, and the story of how FastOMA came to life—and how it works!

Fantastic #Sinergia retreat on #animalorigins! A day packed with insights into #multicellularity, #ichthyosporeans, #choanoflagellates & more—capped with a Swiss-style finale. Huge thanks to 𝘋𝘪𝘳𝘬 Stefano Pascarelli Dave Moi Christophe Dessimoz Pedro Beltrao 🚺

Dessimoz Lab representation at #ISMB2025 * Phylogenies with protein structures, #FoldTree - Dave Moi * Ancestral genome reconstruction: #EdgeHOG - Charles Bernard * Gene duplications and functional evolution Alex WV and Irene Julca