I am very happy to share our recent publication Nature Communications about origin licensing in budding yeast. Had a blast working with Christian Speck, Sarah Victoria, Korbinian Liebl et al. at MRC Laboratory of Medical Sciences (LMS) and Imperial College London. Read about it here and 👇 1/3: rdcu.be/dRTAZ

🧬A new study in Nature Communications by Christian Speck MRC Laboratory of Medical Sciences (LMS) has shown how DNA helicases are equally distributed across the yeast #genome, ensuring accurate #DNAReplication. This could have implications for cancer & age-related diseases in the future. 👉lms.mrc.ac.uk/discovery-of-f…

Make publication ready figures from your #AlphaFold PAE files. Works on multimer and AlphaFold 3 files. Customize colors and export as an SVG for editing in illustrator! thecodingbiologist.com/tools/pae.html

Interested in how cells make decisions? Want to build new tools and model embryonic development using ESCs? Come join us MRC Laboratory of Medical Sciences (LMS)! We have a #postdoc position open in the area of gene regulation, stem cells and mouse development. See how to apply here: lms.mrc.ac.uk/vacancies/mrc-…

Closing on the 13th of October is a Postdoctoral Researcher Scientist role in the Development and Transcriptional Control Group headed by Vicki Metzis lms.mrc.ac.uk/vacancies/mrc-…

Here is the link to the Colab, let us know if you have any problems or you have a hard target our pipeline cannot design against! We want to keep improving it and community feedback is very important 🙏🏻💻 colab.research.google.com/github/martinp…

Does anyone I know on twitter have any old akta purifiers hanging around I can take some parts off?

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Another chance to join us at Birmingham. This time open also to ECRs and junior independent researchers. Genome biology is one of the priority areas (as is cancer and RNA biology). Have a look 😀. Get in touch 😀

One week left to apply for a cryoEM facility manager position University of Sussex If you want to be an integral part of the growing community of researchers imaging the molecules of life in human disease then this is the job for you! jobs.sussex.ac.uk/job/0fc71993-6…

Great kickoff for the EMBO EMBL Replication symposium with amazing structural and functional insights into initiation, elongation and histone recycling 🧬♻️ Bik Tye Costa Lab Bleichert Lab Christian Speck Chistol @Lopes_Lab Méchali @YardimciLab 🙌 #EESReplication EMBL Events

I have two PhD positions available in my group next year! These projects are looking at how disordered regions alter protein dynamics. One is through the Yorkshire BBSRC DTP, advertisement to come, but more information can be found here: whiterose-mechanisticbiology-dtp.ac.uk/yorkshire-bios…

Great science, fantastic opportunity to learn, and an exciting project. I strongly recommend applying.

PREPRINT OUT! Cell cycle regulation is not limited to conserved TFs. Select young TFs (29-105myo) 1) regulate cell cycle genes and 2) set the #ReplicationTiming of gene clusters. Brainchild of Forey Romain and Cyril Pulver. doi.org/10.1101/2024.1…

To all postdocs. Are you ready to start your semi-independent career? The BBSRC Fellowship call is open. We could host you if you work in the area of DNA replication/chromatin/cancer and like to use protein biochemistry, genomics, cryo-EM, AlphaFold, MD… tinyurl.com/bdd2yv8z